Discontinued Product

Andrographolide (Cat. No. 4626) has been withdrawn from sale for commercial reasons.
Cat.No. 4626 - Andrographolide | C20H30O5 | CAS No. 5508-58-7
Description: Inhibits NFκB; blocks androgen receptor (AR) expression
Chemical Name: (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone
Purity: ≥99% (HPLC)
Literature (3)
Pathways (1)

Biological Activity for Andrographolide

Andrographolide is an inhibitor of NF-κB signaling; also attenuates concanavaline-induced IFNγ production in murine T cells (IC50 = 1.7 μM). Blocks androgen receptor (AR) expression in AR-expressing C4-2 cells. Activates Nrf2 in BEAS-2B cells in response to cigarette smoke extract.

Technical Data for Andrographolide

M. Wt 350.45
Formula C20H30O5
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 5508-58-7
PubChem ID 452937
Smiles C=C1CC[C@@]([C@@](CO)(C)[C@H](O)CC3)([H])[C@]3(C)[C@@H]1C/C=C2[C@H](O)COC/2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Andrographolide

References for Andrographolide

References are publications that support the biological activity of the product.

Liu et al (2011) Andrographolide targets androgen receptor pathway in castration-resistant prostate cancer. Genes Cancer. 2 151 PMID: 21779488

Burgos et al (2005) Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis. Planta.Med. 71 429 PMID: 15931581

Guan et al (2012) Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity. Br.J.Pharmacol. [Epub ahead of print] PMID: 23146110

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Keywords: Andrographolide, Andrographolide supplier, nfkb, nrf2, inhibitors, inhibits, androgen, receptors, AR, expression, ifng, ifngamma, interferons, immunosuppressants, NF-kB/IkB, Androgen, Receptor, Nrf2, 4626, Tocris Bioscience

Citations for Andrographolide

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Pathways for Andrographolide

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.