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Discontinued ProductAndrographolide (Cat. No. 4626) has been withdrawn from sale for commercial reasons.
Biological Activity for Andrographolide
Andrographolide is an inhibitor of NF-κB signaling; also attenuates concanavaline-induced IFNγ production in murine T cells (IC50 = 1.7 μM). Blocks androgen receptor (AR) expression in AR-expressing C4-2 cells. Activates Nrf2 in BEAS-2B cells in response to cigarette smoke extract.
Technical Data for Andrographolide
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Andrographolide
References are publications that support the biological activity of the product.
Liu et al (2011) Andrographolide targets androgen receptor pathway in castration-resistant prostate cancer. Genes Cancer. 2 151 PMID: 21779488
Burgos et al (2005) Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis. Planta.Med. 71 429 PMID: 15931581
Guan et al (2012) Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity. Br.J.Pharmacol. [Epub ahead of print] PMID: 23146110
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Keywords: Andrographolide, Andrographolide supplier, nfkb, nrf2, inhibitors, inhibits, androgen, receptors, AR, expression, ifng, ifngamma, interferons, immunosuppressants, NF-kB/IkB, Androgen, Receptor, Nrf2, 4626, Tocris Bioscience
Citations for Andrographolide
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Currently there are no citations for Andrographolide.
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Literature in this Area
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