Andrographolide

Pricing Availability Delivery Time Qty
Cat.No. 4626 - Andrographolide | C20H30O5 | CAS No. 5508-58-7
Description: Inhibits NFκB; blocks androgen receptor (AR) expression
Chemical Name: (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Inhibitor of NF-κB signaling; also attenuates concanavaline-induced IFNγ production in murine T cells (IC50 = 1.7 μM). Blocks androgen receptor (AR) expression in AR-expressing C4-2 cells. Activates Nrf2 in BEAS-2B cells in response to cigarette smoke extract.

Technical Data

M. Wt 350.45
Formula C20H30O5
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 5508-58-7
PubChem ID 452937
InChI Key BOJKULTULYSRAS-UQZPWQSVSA-N
Smiles C=C1CC[C@@]([C@@](CO)(C)[C@H](O)CC3)([H])[C@]3(C)[C@@H]1C/C=C2[C@H](O)COC/2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.05 100
ethanol 3.5 10

Preparing Stock Solutions

The following data is based on the product molecular weight 350.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.27 mL 28.53 mL
5 mM 0.57 mL 2.85 mL 5.71 mL
10 mM 0.29 mL 1.43 mL 2.85 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Liu et al (2011) Andrographolide targets androgen receptor pathway in castration-resistant prostate cancer. Genes Cancer. 2 151 PMID: 21779488

Burgos et al (2005) Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis. Planta.Med. 71 429 PMID: 15931581

Guan et al (2012) Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity. Br.J.Pharmacol. [Epub ahead of print] PMID: 23146110


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Keywords: Andrographolide, supplier, nfkb, nrf2, inhibitors, inhibits, androgen, receptors, AR, expression, ifng, ifngamma, interferons, immunosuppressants, NF-kB/IkB, Tocris Bioscience

Citations for Andrographolide

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Literature in this Area

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Pathways for Andrographolide

NF-κB

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.

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