Inhibitor of NF-κB signaling; also attenuates concanavaline-induced IFNγ production in murine T cells (IC50 = 1.7 μM). Blocks androgen receptor (AR) expression in AR-expressing C4-2 cells. Activates Nrf2 in BEAS-2B cells in response to cigarette smoke extract.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 350.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.85 mL||14.27 mL||28.53 mL|
|5 mM||0.57 mL||2.85 mL||5.71 mL|
|10 mM||0.29 mL||1.43 mL||2.85 mL|
|50 mM||0.06 mL||0.29 mL||0.57 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Liu et al (2011) Andrographolide targets androgen receptor pathway in castration-resistant prostate cancer. Genes Cancer. 2 151 PMID: 21779488
Burgos et al (2005) Andrographolide inhibits IFN-gamma and IL-2 cytokine production and protects against cell apoptosis. Planta.Med. 71 429 PMID: 15931581
Guan et al (2012) Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity. Br.J.Pharmacol. [Epub ahead of print] PMID: 23146110
If you know of a relevant reference for Andrographolide, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Andrographolide, supplier, nfkb, nrf2, inhibitors, inhibits, androgen, receptors, AR, expression, ifng, ifngamma, interferons, immunosuppressants, NF-kB/IkB, Tocris Bioscience
Citations for Andrographolide
Citations are publications that use Tocris products.
Currently there are no citations for Andrographolide. Do you know of a great paper that uses Andrographolide from Tocris? If so please let us know.