Amphotericin B

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Cat.No. 6930 - Amphotericin B | C47H73NO17 | CAS No. 1397-89-3
Description: Forms monovalent ion channels in lipid bilyers; antifungal
Chemical Name: (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
Purity: ≥90% (HPLC)
Literature (1)

Biological Activity

Forms nonselective monovalent ion channels within lipid bilayers. Binds ergosterol in the cell membrane. Antifungal.

Technical Data

M. Wt 924.09
Formula C47H73NO17
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 1397-89-3
PubChem ID 5280965
Smiles [H][C@]12C[C@@H](O[C@]3([H])O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 18.48 20

Preparing Stock Solutions

The following data is based on the product molecular weight 924.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 5.41 mL 27.05 mL 54.11 mL
1 mM 1.08 mL 5.41 mL 10.82 mL
2 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.11 mL 0.54 mL 1.08 mL

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References are publications that support the biological activity of the product.

Muruglia et al (2019) Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia. Nature. 567 405 PMID: 30867598

Gallis et al (1990) Amphotericin B: 30 years of clinical experience. Rev.Infect.Dis. 12 308 PMID: 2184499

Lewis (2011) Current concepts in antifungal pharmacology. Mayo Clin.Proc. 86 805 PMID: 21803962

If you know of a relevant reference for Amphotericin B, please let us know.

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