Amphotericin B

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Cat.No. 6930 - Amphotericin B | C47H73NO17 | CAS No. 1397-89-3
Description: Forms monovalent ion channels in lipid bilyers; antifungal
Chemical Name: (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
Purity: ≥90% (HPLC)
Datasheet
Citations
Reviews
Protocols (1)

Biological Activity for Amphotericin B

Amphotericin B is a forms nonselective monovalent ion channels within lipid bilayers. Binds ergosterol in the cell membrane. Antifungal.

Technical Data for Amphotericin B

M. Wt 924.09
Formula C47H73NO17
Storage Store at -20°C
Purity ≥90% (HPLC)
CAS Number 1397-89-3
PubChem ID 5280965
InChI Key APKFDSVGJQXUKY-INPOYWNPSA-N
Smiles [H][C@]12C[C@@H](O[C@]3([H])O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Amphotericin B

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.48 20

Preparing Stock Solutions for Amphotericin B

The following data is based on the product molecular weight 924.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 5.41 mL 27.05 mL 54.11 mL
1 mM 1.08 mL 5.41 mL 10.82 mL
2 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.11 mL 0.54 mL 1.08 mL

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Product Datasheets for Amphotericin B

References for Amphotericin B

References are publications that support the biological activity of the product.

Muruglia et al (2019) Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia. Nature. 567 405 PMID: 30867598

Gallis et al (1990) Amphotericin B: 30 years of clinical experience. Rev.Infect.Dis. 12 308 PMID: 2184499

Lewis (2011) Current concepts in antifungal pharmacology. Mayo Clin.Proc. 86 805 PMID: 21803962


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Citations for Amphotericin B

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Protocols for Amphotericin B

The following protocol features additional information for the use of Amphotericin B (Cat. No. 6930).