Amlodipine besylate

Cat. No. 2571 2 Citations Datasheet / COA / SDS

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Cat.No. 2571 - Amlodipine besylate | C20H25ClN2O5.C6H6O3S | CAS No. 111470-99-6

Description: Ca²⁺ channel blocker (L-type)

Alternative Names: Norvasc

Chemical Name: 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate

Purity: ≥99% (HPLC)

Datasheet

Citations (2)

Reviews

Literature

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca²⁺-induced contractions in depolarized rat aorta (IC₅₀ = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC₅₀ = 25 μM).

Compound Libraries

Amlodipine besylate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	567.05
Formula	C₂₀H₂₅ClN₂O₅.C₆H₆O₃S
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	111470-99-6
PubChem ID	60496
InChI Key	ZPBWCRDSRKPIDG-UHFFFAOYSA-N
Smiles	OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	56.7	100
	water	5.67	10

Preparing Stock Solutions

The following data is based on the product molecular weight 567.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.76 mL	8.82 mL	17.64 mL
5 mM	0.35 mL	1.76 mL	3.53 mL
10 mM	0.18 mL	0.88 mL	1.76 mL
50 mM	0.04 mL	0.18 mL	0.35 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet

Safety Datasheet

References

References are publications that support the products' biological activity.

Burges et al (1987) Calcium channel blocking properties of amlodipine in vascular smooth muscle and cardiac muscle in vitro: evidence for voltage modulation of vascular dihydropyridine receptors. J.Cardiovasc.Pharmacol. 9 110 PMID: 2434785

Yoshida et al (2003) Antiproliferative effect of Ca²⁺ channel blockers on human epidermoid carcinoma A431 cells. Eur.J.Pharmacol. 472 23 PMID: 12860469

Toba et al (2005) Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the N^G-nitro-L-arginine methyl ester-induced hype Hypertens.Res. 28 689 PMID: 16392774

If you know of a relevant reference for Amlodipine besylate, please let us know.

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2 Citations for Amlodipine besylate

Citations are publications that use Tocris products. Selected citations for Amlodipine besylate include:

Zhong et al (2014) Serotonin 5-HT3 receptor-mediated vomiting occurs via the activation of Ca2+/CaMKII-dependent ERK1/2 signaling in the least shrew (Cryptotis parva). PLoS One 9 e104718 PMID: 25121483

Sharma et al (2016) Suppression of protective responses upon activation of L-type voltage gated calcium channel in macrophages during mycobacterium bovis BCG infection PLoS One 11 e0163845 PMID: 27723836

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

Hypertension
Thrombosis and Hemostasis
Atherosclerosis
Myocardial Infarction
Ischemia/Reperfusion Injury
Arrhythmias
Heart Failure

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

Nociception
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Intracellular Signaling

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.