Ambroxol hydrochloride

Discontinued Product

Ambroxol hydrochloride (Cat. No. 2404) has been withdrawn from sale for commercial reasons.
Description: Na+ channel blocker
Chemical Name: trans-4-[[(2-Amino-3,5-dibromophenyl)methyl]amino]cyclohexanol hydrochloride
Purity: ≥99% (HPLC)
Literature (5)

Biological Activity for Ambroxol hydrochloride

Ambroxol hydrochloride is a sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC50 values for tonic block are 35.2 and 111.5 μM respectively). Inhibits release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. Inhibits viral replication and improves survival rate of mice infected with influenza (H3N2) virus.

Compound Libraries for Ambroxol hydrochloride

Ambroxol hydrochloride is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Ambroxol hydrochloride

M. Wt 414.57
Formula C13H18Br2N2O.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 23828-92-4
PubChem ID 108013
Smiles NC1=C(Br)C=C(Br)C=C1CN[C@H]2CC[C@H](O)CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Ambroxol hydrochloride

References for Ambroxol hydrochloride

References are publications that support the biological activity of the product.

Gillissen et al (1997) Antioxidant function of ambroxol in mononuclear and polymorphonuclear cells in vitro. Lung 175 235 PMID: 9195551

Gibbs et al (1999) Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. Inflamm.Res. 48 86 PMID: 10202994

Weiser and Wilson (2002) Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na+ channels by the secretolytic ambroxol. Mol.Pharmacol. 62 433 PMID: 12181417

Yang et al (2002) Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels. Eur.Respir.J. 19 952 PMID: 12030738

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Keywords: Ambroxol hydrochloride, Ambroxol hydrochloride supplier, Na+, channel, blockers, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Voltage-gated, Influenza, Viruses, 2404, Tocris Bioscience

Citations for Ambroxol hydrochloride

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