Ambroxol hydrochloride

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Cat.No. 2404 - Ambroxol hydrochloride | C13H18Br2N2O.HCl | CAS No. 23828-92-4
Description: Na+ channel blocker
Chemical Name: trans-4-[[(2-Amino-3,5-dibromophenyl)methyl]amino]cyclohexanol hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties. Inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC50 values for tonic block are 35.2 and 111.5 μM respectively). Inhibits release of histamine, leukotrienes and cytokines from human leukocytes and mast cells.

Compound Libraries

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Technical Data

M. Wt 414.57
Formula C13H18Br2N2O.HCl
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 23828-92-4
PubChem ID 108013
InChI Key QNVKOSLOVOTXKF-UHFFFAOYSA-N
Smiles NC1=C(Br)C=C(Br)C=C1CN[C@H]2CC[C@H](O)CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.72 50

Preparing Stock Solutions

The following data is based on the product molecular weight 414.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.82 mL 24.12 mL 48.24 mL
2.5 mM 0.96 mL 4.82 mL 9.65 mL
5 mM 0.48 mL 2.41 mL 4.82 mL
25 mM 0.1 mL 0.48 mL 0.96 mL

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References

References are publications that support the biological activity of the product.

Gillissen et al (1997) Antioxidant function of ambroxol in mononuclear and polymorphonuclear cells in vitro. Lung 175 235 PMID: 9195551

Gibbs et al (1999) Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. Inflamm.Res. 48 86 PMID: 10202994

Weiser and Wilson (2002) Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na+ channels by the secretolytic ambroxol. Mol.Pharmacol. 62 433 PMID: 12181417


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