AGN 193109

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Cat.No. 5758 - AGN 193109 | C28H24O2 | CAS No. 171746-21-7
Description: High affinity pan-RAR antagonist
Chemical Name: 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic acid
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity pan-retinoic acid receptor (RAR) antagonist (Kd values are 2, 2 and 3 nM at RARα, RARβ and RARγ, respectively). Exhibits no significant affinity for retinoic X receptors.

Technical Data

M. Wt 392.49
Formula C28H24O2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 171746-21-7
PubChem ID 177238
InChI Key NCEQLLNVRRTCKJ-UHFFFAOYSA-N
Smiles CC(CC=C1C2=CC=C(C)C=C2)(C)C(C1=C3)=CC=C3C#CC4=CC=C(C(O)=O)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.85 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 392.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.48 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Agarwal et al (1996) AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. J.Biol.Chem. 271 12209 PMID: 8647816

Levi et al (2015) Saturated fatty acids regulate retinoic acid signalling and suppress tumorigenesis by targeting fatty acid-binding protein 5 Nat.Commun. 6 8794 PMID: 26592976

Jaurena et al (2015) Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport. Nat.Commun. 6 7476 PMID: 26101153


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Keywords: AGN193109 high affinity selective retinoic acid receptors RAR antagonists antagonisms Retinoic Acid Receptors

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