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High affinity pan-retinoic acid receptor (RAR) antagonist (Kd values are 2, 2 and 3 nM at RARα, RARβ and RARγ, respectively). Exhibits no significant affinity for retinoic X receptors.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||1.96||5 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 392.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||50.96 mL||254.78 mL||509.57 mL|
|0.25 mM||10.19 mL||50.96 mL||101.91 mL|
|0.5 mM||5.1 mL||25.48 mL||50.96 mL|
|2.5 mM||1.02 mL||5.1 mL||10.19 mL|
References are publications that support the biological activity of the product.
Agarwal et al (1996) AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. J.Biol.Chem. 271 12209 PMID: 8647816
Levi et al (2015) Saturated fatty acids regulate retinoic acid signalling and suppress tumorigenesis by targeting fatty acid-binding protein 5 Nat.Commun. 6 8794 PMID: 26592976
Jaurena et al (2015) Zic1 controls placode progenitor formation non-cell autonomously by regulating retinoic acid production and transport. Nat.Commun. 6 7476 PMID: 26101153
If you know of a relevant reference for AGN 193109, please let us know.
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Keywords: AGN 193109, AGN 193109 supplier, AGN193109, high, affinity, selective, retinoic, acid, receptors, RAR, antagonists, antagonisms, Retinoic, Acid, Receptors, 5758, Tocris Bioscience
3 Citations for AGN 193109
Citations are publications that use Tocris products. Selected citations for AGN 193109 include:
Moreau et al (2019) Timed Collinear Activation of Hox Genes during Gastrulation Controls the Avian Forelimb Position. Curr Biol 29 35 PMID: 30554902
Blixt et al (2018) Zinc finger gene nolz1 regulates the formation of retinal progenitor cells and suppresses the Lim3/Lhx3 phenotype of retinal bipolar cells in chicken retina. Dev Dyn 247 630 PMID: 29139167
Jian et al (2018) Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma. Cell Mol Gastroenterol Hepatol 6 429 PMID: 30258965
Do you know of a great paper that uses AGN 193109 from Tocris? Please let us know.
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