8-Chloroadenosine

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Cat.No. 4436 - 8-Chloroadenosine | C10H12ClN5O4 | CAS No. 34408-14-5
Description: Cytotoxic nucleoside analog; inhibits RNA synthesis
Chemical Name: 6-Amino-8-chloropurine riboside
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.

Technical Data

M. Wt 301.69
Formula C10H12ClN5O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 34408-14-5
PubChem ID 90488943
InChI Key MHDPPLULTMGBSI-LZGMGDPASA-N
Smiles O[C@@H]1[C@@H](CO)OC(N3C2=NC=NC(N)=C2N=C3Cl)[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.17 100
water 6.03 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 301.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.31 mL 16.57 mL 33.15 mL
5 mM 0.66 mL 3.31 mL 6.63 mL
10 mM 0.33 mL 1.66 mL 3.31 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Zhang et al (2004) Exposure of human lung cancer cells to 8-chloro-adenosine induces G2/M arrest and mitotic catastrophe. Neoplasia 6 802 PMID: 15720807

Gu et al (2006) 8-Chloro-adenosine inhibits growth at least partly by interfering with actin polymerization in cultured human lung cancer cells Biochem.Pharmacol. 72 541 PMID: 16844099

Cervantes-Gomez et al (2011) ATP analog enhances the actions of a heat shock protein 90 inhibitor in multiple myeloma cells. J.Pharmacol.Exp.Ther. 339 545 PMID: 21821695


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1 Citation for 8-Chloroadenosine

Citations are publications that use Tocris products. Selected citations for 8-Chloroadenosine include:

Kearney et al (2015) 8-Chloroadenosine Sensitivity in Renal Cell Carcinoma Is Associated with AMPK Activation and mTOR Pathway Inhibition. PLoS One 10 e0135962 PMID: 26313261


Do you know of a great paper that uses 8-Chloroadenosine from Tocris? If so please let us know.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for 8-Chloroadenosine

Protocols

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