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Description: Potent and selective GSK-3β inhibitor
Chemical Name: 5-Ethyl-7,8-dimethoxy-1H-pyrrolo[3,4-c]isoquinoline-1,3(2H)-dione
Purity: ≥99% (HPLC)
Biological Activity for 3F8
3F8 is a potent and selective GSK-3β inhibitor (IC50 values are 34 and 304 nM in the presence of 10 and 100 μM ATP respectively).
Compound Libraries for 3F8
3F8 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for 3F8
| M. Wt | 286.28 |
| Formula | C15H14N2O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 159109-11-2 |
| PubChem ID | 23829003 |
| InChI Key | ULVWJFBHQIXEPE-UHFFFAOYSA-N |
| Smiles | O=C(NC3=O)C2=C3C1=CC(OC)=C(OC)C=C1C(CC)=N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 3F8
References for 3F8
References are publications that support the biological activity of the product.
Zhong et al (2009) Characterization and development of novel small-molecules inhibiting GSK3 and activating wnt signaling. Mol.Biosyst. 5 1356 PMID: 19823752
Zou et al (2010) Benzo[e]isoindole-1,3-diones as potential inhibitors of glycogen synthase kinase-3 (GSK-3). Synthesis, kinase inhibitory activity, zebrafish phenotype, and modeling of binding mode. J.Med.Chem. 53 994 PMID: 20030405
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Keywords: 3F8, 3F8 supplier, glycogen, synthase, kinase, gsk-3, inhibitors, inhibits, Glycogen, Synthase, Kinase, 3, 4083, Tocris Bioscience
Citations for 3F8
Citations are publications that use Tocris products.
Currently there are no citations for 3F8.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Pathways for 3F8
