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3F8

Cat. No. 4083 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective GSK-3β inhibitor
Chemical Name: 5-Ethyl-7,8-dimethoxy-1H-pyrrolo[3,4-c]isoquinoline-1,3(2H)-dione
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (5)
Pathways (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for 3F8

3F8 is a potent and selective GSK-3β inhibitor (IC50 values are 34 and 304 nM in the presence of 10 and 100 μM ATP respectively).

Compound Libraries for 3F8

3F8 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 3F8

M. Wt 286.28
Formula C15H14N2O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 159109-11-2
PubChem ID 23829003
InChI Key ULVWJFBHQIXEPE-UHFFFAOYSA-N
Smiles O=C(NC3=O)C2=C3C1=CC(OC)=C(OC)C=C1C(CC)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 3F8

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.16 25

Preparing Stock Solutions for 3F8

The following data is based on the product molecular weight 286.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 13.97 mL 69.86 mL 139.72 mL
1.25 mM 2.79 mL 13.97 mL 27.94 mL
2.5 mM 1.4 mL 6.99 mL 13.97 mL
12.5 mM 0.28 mL 1.4 mL 2.79 mL

Molarity Calculator

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References for 3F8

References are publications that support the biological activity of the product.

Zhong et al (2009) Characterization and development of novel small-molecules inhibiting GSK3 and activating wnt signaling. Mol.Biosyst. 5 1356 PMID: 19823752

Zou et al (2010) Benzo[e]isoindole-1,3-diones as potential inhibitors of glycogen synthase kinase-3 (GSK-3). Synthesis, kinase inhibitory activity, zebrafish phenotype, and modeling of binding mode. J.Med.Chem. 53 994 PMID: 20030405

If you know of a relevant reference for 3F8, please let us know.

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Keywords: 3F8, 3F8 supplier, glycogen, synthase, kinase, gsk-3, inhibitors, inhibits, Glycogen, Synthase, Kinase, 3, 4083, Tocris Bioscience

Citations for 3F8

Citations are publications that use Tocris products.

Currently there are no citations for 3F8. Do you know of a great paper that uses 3F8 from Tocris? Please let us know.

Reviews for 3F8

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Pathways for 3F8

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.