Pricing Availability   Qty
Description: Potent and selective GSK-3β inhibitor
Chemical Name: 5-Ethyl-7,8-dimethoxy-1H-pyrrolo[3,4-c]isoquinoline-1,3(2H)-dione
Purity: ≥99% (HPLC)
Literature (4)
Pathways (1)

Biological Activity for 3F8

3F8 is a potent and selective GSK-3β inhibitor (IC50 values are 34 and 304 nM in the presence of 10 and 100 μM ATP respectively).

Compound Libraries for 3F8

3F8 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 3F8

M. Wt 286.28
Formula C15H14N2O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 159109-11-2
PubChem ID 23829003
Smiles O=C(NC3=O)C2=C3C1=CC(OC)=C(OC)C=C1C(CC)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for 3F8

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 7.16 25

Preparing Stock Solutions for 3F8

The following data is based on the product molecular weight 286.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 13.97 mL 69.86 mL 139.72 mL
1.25 mM 2.79 mL 13.97 mL 27.94 mL
2.5 mM 1.4 mL 6.99 mL 13.97 mL
12.5 mM 0.28 mL 1.4 mL 2.79 mL

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References for 3F8

References are publications that support the biological activity of the product.

Zhong et al (2009) Characterization and development of novel small-molecules inhibiting GSK3 and activating wnt signaling. Mol.Biosyst. 5 1356 PMID: 19823752

Zou et al (2010) Benzo[e]isoindole-1,3-diones as potential inhibitors of glycogen synthase kinase-3 (GSK-3). Synthesis, kinase inhibitory activity, zebrafish phenotype, and modeling of binding mode. J.Med.Chem. 53 994 PMID: 20030405

If you know of a relevant reference for 3F8, please let us know.

View Related Products by Product Action

View all Glycogen Synthase Kinase 3 Inhibitors

Keywords: 3F8, 3F8 supplier, glycogen, synthase, kinase, gsk-3, inhibitors, inhibits, Glycogen, Synthase, Kinase, 3, 4083, Tocris Bioscience

Citations for 3F8

Citations are publications that use Tocris products.

Currently there are no citations for 3F8. Do you know of a great paper that uses 3F8 from Tocris? Please let us know.

Reviews for 3F8

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

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Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

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Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for 3F8

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.