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Cat.No. 4083 - 3F8 | C15H14N2O4 | CAS No. 159109-11-2
Description: Potent and selective GSK-3β inhibitor
Chemical Name: 5-Ethyl-7,8-dimethoxy-1H-pyrrolo[3,4-c]isoquinoline-1,3(2H)-dione
Purity: ≥99% (HPLC)
Literature (5)

Biological Activity

Potent and selective GSK-3β inhibitor (IC50 values are 34 and 304 nM in the presence of 10 and 100 μM ATP respectively).

Technical Data

M. Wt 286.28
Formula C15H14N2O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 159109-11-2
PubChem ID 23829003
Smiles O=C(NC3=O)C2=C3C1=CC(OC)=C(OC)C=C1C(CC)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 7.16 25

Preparing Stock Solutions

The following data is based on the product molecular weight 286.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 13.97 mL 69.86 mL 139.72 mL
1.25 mM 2.79 mL 13.97 mL 27.94 mL
2.5 mM 1.4 mL 6.99 mL 13.97 mL
12.5 mM 0.28 mL 1.4 mL 2.79 mL

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References are publications that support the biological activity of the product.

Zhong et al (2009) Characterization and development of novel small-molecules inhibiting GSK3 and activating wnt signaling. Mol.Biosyst. 5 1356 PMID: 19823752

Zou et al (2010) Benzo[e]isoindole-1,3-diones as potential inhibitors of glycogen synthase kinase-3 (GSK-3). Synthesis, kinase inhibitory activity, zebrafish phenotype, and modeling of binding mode. J.Med.Chem. 53 994 PMID: 20030405

If you know of a relevant reference for 3F8, please let us know.

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Keywords: 3F8, 3F8 supplier, glycogen, synthase, kinase, gsk-3, inhibitors, inhibits, Glycogen, Synthase, Kinase, 3, 4083, Tocris Bioscience

Citations for 3F8

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