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Submit Review2B-(SP)
Discontinued Product
2B-(SP) (Cat. No. 1802) has been withdrawn from sale for commercial reasons.
Description: Selective GSK-3 phosphopeptide substrate
Biological Activity for 2B-(SP)
2B-(SP) is a selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3); derived from the phosphorylation site of the translation factor eIF2B.
Technical Data for 2B-(SP)
| M. Wt | 1835.88 |
| Formula | C71H123N26O29P |
| Sequence |
RRAAEELDSRAGSPQL (Modifications: Ser-13 = pSer) |
| Storage | Desiccate at -20°C |
| CAS Number | 186901-17-7 |
| PubChem ID | 90488714 |
| InChI Key | LBVCQYQHTKHZRY-APZQELAWSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](COP(O)(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 2B-(SP)
References for 2B-(SP)
References are publications that support the biological activity of the product.
Welsh et al (1997) Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts. Anal.Biochem. 244 16 PMID: 9025901
Williams et al (1999) Phosphorylated seryl and threonyl, but not tyrosyl, residues are efficient specificity determinants for GSK-3β and Shaggy. FEBS Lett. 448 86 PMID: 10217415
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Keywords: 2B-(SP), 2B-(SP) supplier, Selective, GSK-3, phosphopeptide, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, Enzyme, Substrates, activators, 2BSP, /, Activators, Kinase, 1802, Tocris Bioscience
Citations for 2B-(SP)
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