Biological Activity
Selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3); derived from the phosphorylation site of the translation factor eIF2B.
Technical Data
M. Wt | 1835.88 |
Formula | C71H123N26O29P |
Sequence |
RRAAEELDSRAGSPQL (Modifications: Ser-13 = pSer) |
Storage | Desiccate at -20°C |
CAS Number | 186901-17-7 |
PubChem ID | 90488714 |
InChI Key | LBVCQYQHTKHZRY-APZQELAWSA-N |
Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](COP(O)(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
Solubility | Soluble to 1 mg/ml in water |
Product Datasheets
References
References are publications that support the biological activity of the product.
Welsh et al (1997) Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts. Anal.Biochem. 244 16 PMID: 9025901
Williams et al (1999) Phosphorylated seryl and threonyl, but not tyrosyl, residues are efficient specificity determinants for GSK-3β and Shaggy. FEBS Lett. 448 86 PMID: 10217415
If you know of a relevant reference for 2B-(SP), please let us know.
View Related Products by Target
Keywords: 2B-(SP), 2B-(SP) supplier, Selective, GSK-3, phosphopeptide, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, Enzyme, Substrates, activators, 2BSP, /, Activators, Kinase, 1802, Tocris Bioscience
Citations for 2B-(SP)
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