2B-(SP)
Biological Activity
Selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3); derived from the phosphorylation site of the translation factor eIF2B.
Technical Data
| M. Wt | 1835.88 |
| Formula | C71H123N26O29P |
| Sequence |
RRAAEELDSRAGSPQL (Modifications: Ser-13 = pSer) |
| Storage | Desiccate at -20°C |
| CAS Number | 186901-17-7 |
| PubChem ID | 90488714 |
| InChI Key | LBVCQYQHTKHZRY-APZQELAWSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](COP(O)(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1835.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.54 mL | 2.72 mL | 5.45 mL |
| 5 mM | 0.11 mL | 0.54 mL | 1.09 mL |
| 10 mM | 0.05 mL | 0.27 mL | 0.54 mL |
| 50 mM | 0.01 mL | 0.05 mL | 0.11 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Welsh et al (1997) Peptide substrates suitable for assaying glycogen synthase kinase-3 in crude cell extracts. Anal.Biochem. 244 16 PMID: 9025901
Williams et al (1999) Phosphorylated seryl and threonyl, but not tyrosyl, residues are efficient specificity determinants for GSK-3β and Shaggy. FEBS Lett. 448 86 PMID: 10217415
If you know of a relevant reference for 2B-(SP), please let us know.
View Related Products by Target
Keywords: 2B-(SP), supplier, Selective, GSK-3, phosphopeptide, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, Enzyme, Substrates, activators, 2BSP, Enzyme, Substrates, /, Activators, Glycogen, Synthase, Kinase, 3, Glycogen, Synthase, Kinase, Enzyme, Substrates, /, Activators, Tocris Bioscience
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