Activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|tris buffer solution||5.35||33mM with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 162.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||6.17 mL||30.83 mL||61.66 mL|
|5 mM||1.23 mL||6.17 mL||12.33 mL|
|10 mM||0.62 mL||3.08 mL||6.17 mL|
|50 mM||0.12 mL||0.62 mL||1.23 mL|
References are publications that support the products' biological activity.
Ayotunde and Adeagbo (1999) 1-Ethyl-2-benzimidazolinone stimulates endothelial KCa channels and nitric oxide formation in rat mesenteric vessels. Eur.J.Pharmacol. 379 151 PMID: 10497901
Devor et al (1996) Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca2+ - dependent K+ channel. Am.J.Physiol. 271 L775 PMID: 8944721
Kusama et al (2005) Reduced hyperpolarisation in endothelial cells of rabbit aortic value following chronic nitroglycerine administration. Br.J.Pharmacol. 146 487 PMID: 16056232
Kleger et al (2010) Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells. Circulation. 122 1823 PMID: 20956206
If you know of a relevant reference for 1-EBIO, please let us know.
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Keywords: 1-EBIO, supplier, Activator, epithelial, Kca, channels, Potassium, Channels, ca2+-activated, ca2+-dependent, K+, Ca2+-Activated, Potassium, Channels, Cardiomyocyte, Stem, Cells, ESCs, and, iPSC, Ca2+-Activated, Potassium, Channels, Tocris Bioscience
7 Citations for 1-EBIO
Citations are publications that use Tocris products. Selected citations for 1-EBIO include:
Manaves et al (2004) Calcium and Vitamin D increase mRNA levels for the growth control hIK1 channel in human epidermal keratinocytes but functional channels are not observed. Korean J Physiol Pharmacol 4 7 PMID: 15200683
Rau et al (2015) Increased Basolateral Amygdala Pyramidal Cell Excitability May Contribute to the Anxiogenic Phenotype Induced by Chronic Early-Life Stress. BMC Dermatol 35 9730 PMID: 26134655
Duffy et al (2007) Adenosine closes the K+ channel KCa3.1 in human lung mast cells and inhibits their migration via the adenosine A2A receptor. Proc Natl Acad Sci U S A 37 1653 PMID: 17474152
Benton et al (2013) Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. J Neurophysiol 109 2528 PMID: 23446695
Cuppoletti et al (2013) Methadone but not morphine inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents. Cell Biochem Biophys 66 53 PMID: 22918821
Choi et al (2013) Contradictory Effects of Superoxide and Hydrogen Peroxide on KCa3.1 in Human Endothelial Cells. Eur J Immunol 17 181 PMID: 23776393
Cruse et al (2011) Functional KCa3.1 K+ channels are required for human fibrocyte migration. J Allergy Clin Immunol 128 1303 PMID: 21872912
Do you know of a great paper that uses 1-EBIO from Tocris? If so please let us know.
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New Product Guide (Spring/Summer 2017)
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
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