Urotensin-II Receptors

The urotensin-II (UT) receptor is a Gq/11-protein-coupled receptor that mediates complex hemodynamic effects and influences neuromuscular physiology. The UT receptor displays greatest expression levels in the peripheral vasculature, heart and kidney.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
2484 (±)-AC 7954 hydrochloride
Non-peptide UT receptor agonist
1642 Urotensin II (human)
Endogenous vasoactive agonist for the UT receptor

Antagonists

Cat No Product Name / Activity
5110 GSK 1562590 hydrochloride
High affinity, selective urotensin II (UT) receptor antagonist
4670 SB 611812
Urotensin-II (UT) antagonist; attenuates cardiac dysfunction
3571 SB 657510
Selective urotensin-II (UT) receptor antagonist
4667 SB 706375
High affinity, non-peptide UT receptor antagonist
2529 UFP 803
Urotensin-II (UT) antagonist
5296 Urantide
Selective and competitive urotensin II receptor antagonist
3162 [Orn5]-URP
Urotensin-II (UT) receptor antagonist

The urotensin-II (UT) receptor is a Gq/11-protein-coupled receptor that mediates complex hemodynamic effects and influences neuromuscular physiology. The UT receptor displays greatest expression levels in the peripheral vasculature, heart and kidney, although they are found elsewhere, notably the central nervous system, at lower levels.

The UT receptor produces potent but variable vasoconstrictor effects in some vascular beds, yet mediates vasodilation in others; it has also been implicated in osmoregulation. The human gene encoding the UT receptor is located on chromosome 17q25.3.

External sources of pharmacological information for Urotensin-II Receptors :

Literature for Urotensin-II Receptors

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

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GPCR

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Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

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Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Urotensin-II Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human UTS2R NM_018949 Q9UKP6
Mouse Uts2r NM_145440 Q8VIH9
Rat Uts2r NM_020537 P49684