Neuromedin U Receptors

Neuromedin U (NMU) receptors are a group of Gq/11-protein-coupled receptors that are currently divided into two subtypes: NMU1 and NMU2. The two subtypes have distinct tissue distributions: NMU1 is expressed in the periphery, whilst NMU2 is expressed in the CNS.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
3648 Neuromedin S (rat)
Potent, endogenous NMU1 and NMU2 agonist
1917 Neuromedin U (rat)
Endogenous modulator of blood pressure and flow, gut ion transport, feeding and body temperature

Neuromedin U (NMU) receptors are a group of Gq/11-protein-coupled receptors that are currently divided into two subtypes: NMU1 and NMU2. The two subtypes have distinct tissue distributions: NMU1 is expressed in the periphery (especially in the gastrointestinal tract), whilst NMU2 is expressed in the central nervous system (especially in the substantia nigra, medulla oblongata and pontine reticular formation).

NMU receptors mediate diverse biological effects including contraction of the uterus, peripheral vasoconstriction causing hypertension and activation of the HPA axis resulting in decreased food intake via the CRH system. The human genes encoding NMU1 and NMU2 are located on chromosomes 2q37.1 and 5q33.1 respectively.

External sources of pharmacological information for Neuromedin U Receptors :

Literature for Neuromedin U Receptors

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing

Neuromedin U Receptor Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
NMU1 Human NMUR1 NM_006056 Q9HB89
Mouse Nmur1 NM_010341 O55040
Rat Nmur1 NM_023100 Q9JJI5
NMU2 Human NMUR2 NM_020167 Q9GZQ4
Mouse Nmur2 NM_153079 Q8BZ39
Rat Nmur2 NM_022275 Q9ESQ4