Neuromedin U Receptors

Neuromedin U (NMU) receptors are a group of G_q/11-protein-coupled receptors that are currently divided into two subtypes: NMU₁ and NMU₂. The two subtypes have distinct tissue distributions: NMU₁ is expressed in the periphery (especially in the gastrointestinal tract), whilst NMU₂ is expressed in the central nervous system (especially in the substantia nigra, medulla oblongata and pontine reticular formation).

NMU receptors mediate diverse biological effects including contraction of the uterus, peripheral vasoconstriction causing hypertension and activation of the HPA axis resulting in decreased food intake via the CRH system. The human genes encoding NMU₁ and NMU₂ are located on chromosomes 2q37.1 and 5q33.1 respectively.

External sources of pharmacological information for Neuromedin U Receptors :

• IUPHAR Receptor Code

• BJP Guide

Literature for Neuromedin U Receptors

Tocris offers the following scientific literature for Neuromedin U Receptors to showcase our products. We invite you to request* your copy today!

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GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

• Rhodopsin-like Receptors
• Glutamate Receptors
• Frizzled Receptors
• GPCR Signaling

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Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

• Anterior Pituitary Regulation
• Blood Pressure Regulation
• Feeding and Appetite Regulation
• Glucose Regulation
• Peptide Hormone Processing

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Neuromedin U Receptor Gene Data