Kisspeptin Receptor

The kisspeptin receptor (also known as the KISS1 receptor) is a G_q/G₁₁-protein-coupled receptor that signals through stimulation of phospholipase C. The kisspeptin receptor plays a key role in the neuroendocrine control of the gonadotrophin axis.

Products

Background

Literature (3)

Gene Data

Agonists
Cat. No.	Product Name / Activity
5347	Kisspeptin 10 (dog)
	Endogenous ligand for canine kisspeptin receptor
2570	Kisspeptin 10 (human)
	Endogenous ligand for kisspeptin receptor
4243	Kisspeptin 10 (rat)
	Endogenous ligand for kisspeptin receptor
1443	Metastin (human)
	Potent, endogenous ligand for kisspeptin receptor
Antagonists
Cat. No.	Product Name / Activity
3881	Kisspeptin 234
	Kisspeptin receptor antagonist; kisspeptin 10 (Cat. No. 2570) analog

The kisspeptin receptor (also known as the KISS1 receptor) is a G_q/G₁₁-protein-coupled receptor that signals through stimulation of phospholipase C resulting in Ca²⁺ mobilization. The kisspeptin receptor is found at high concentrations in the pancreas, placenta and brain and there are lower expression levels in the small intestine, kidney, lung, liver and heart.

The kisspeptin receptor plays a key role in the neuroendocrine control of the gonadotrophin axis and has been implicated in the inhibition of metastasis. The human KISS1 receptor gene is localized on chromosome 19p13.3.

External sources of pharmacological information for Kisspeptin Receptor :

IUPHAR Receptor Code

BJP Guide

Literature for Kisspeptin Receptor

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