Kisspeptin 10 (human)

Pricing Availability   Qty
Description: Endogenous ligand for kisspeptin receptor
Alternative Names: Metastin (45-54), Kp-10
Purity: ≥95% (HPLC)
Datasheet
Citations (5)
Reviews

Biological Activity for Kisspeptin 10 (human)

Kisspeptin 10 (human) is a potent endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki values of 1.59 and 2.33 nM respectively. Inhibits metastasis and invasion in mouse melanomas and stimulates gonadotropin secretion following i.c.v. administration.

Analog also available.

Technical Data for Kisspeptin 10 (human)

M. Wt 1302.45
Formula C63H83N17O14
Sequence YNWNSFGLRF

(Modification: Phe-10 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 374675-21-5
PubChem ID 25240297
InChI Key RITKWYDZSSQNJI-INXYWQKQSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Kisspeptin 10 (human)

Solubility Soluble to 1 mg/ml in water

Product Datasheets for Kisspeptin 10 (human)

Certificate of Analysis / Product Datasheet
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References for Kisspeptin 10 (human)

References are publications that support the biological activity of the product.

Kotani et al (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J.Biol.Chem. 276 34631 PMID: 11457843

Peilecka-Fortuna et al (2007) Kisspeptin acts directly and indirectly to increase GnRH neuron activity and its effects are modulated by OE. Endocrinology 149 1979 PMID: 18162521

Becker et al (2005) Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumour cells through a specific transcriptional program not shared by other Gq-coupled receptors. Biochem.Biophys.Res.Comm. 326 677


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Keywords: Kisspeptin 10 (human), Kisspeptin 10 (human) supplier, Endogenous, ligands, KISS1, receptors, hOT7T175/AXOR12/GPR54, Metastin, KISS-derived, Peptide, Kisspeptin10, (45-54), Kp-10, Kisspeptin, Receptor, 2570, Tocris Bioscience

5 Citations for Kisspeptin 10 (human)

Citations are publications that use Tocris products. Selected citations for Kisspeptin 10 (human) include:

Wu et al (2013) Kisspeptin-10 enhanced egg production in quails associated with the increase of triglyceride synthesis in liver. Asian-Australas J Anim Sci 26 1080 PMID: 25049888

Wu et al (2012) Effects of kisspeptin-10 on lipid metabolism in cultured chicken hepatocytes. Asian-Australas J Anim Sci 25 1229 PMID: 25049685

Schwetz et al (2014) Differential stimulation of Ins secretion by GLP-1 and Kisspeptin-10. PLoS One 9 e113020 PMID: 25401335

Constantin and Wray (2016) Galanin Activates G Protein Gated Inwardly Rectifying Potassium Channels and Suppresses Kisspeptin-10 Activation of GnRH Neurons. Endocrinology 157 3197 PMID: 27359210


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