Kisspeptin 10 (human)

Pricing Availability   Qty
Cat.No. 2570 - Kisspeptin 10 (human) | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 | CAS No. 374675-21-5
Description: Endogenous ligand for kisspeptin receptor
Alternative Names: Metastin (45-54), Kp-10
Datasheet
Citations (5)
Reviews
Literature

Biological Activity

Potent endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki values of 1.59 and 2.33 nM respectively. Inhibits metastasis and invasion in mouse melanomas and stimulates gonadotropin secretion following i.c.v. administration.

Analog also available.

Technical Data

M. Wt 1302.45
Formula C63H83N17O14
Sequence YNWNSFGLRF

(Modifications: Phe-10 = C-terminal amide)

Storage Desiccate at -20°C
CAS Number 374675-21-5
PubChem ID 25240297
InChI Key RITKWYDZSSQNJI-INXYWQKQSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Kotani et al (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J.Biol.Chem. 276 34631 PMID: 11457843

Peilecka-Fortuna et al (2007) Kisspeptin acts directly and indirectly to increase GnRH neuron activity and its effects are modulated by estradiol. Endocrinology 149 1979 PMID: 18162521

Becker et al (2005) Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumour cells through a specific transcriptional program not shared by other Gq-coupled receptors. Biochem.Biophys.Res.Comm. 326 677


If you know of a relevant reference for Kisspeptin 10 (human), please let us know.

View Related Products by Product Action

View all Kisspeptin Receptor Agonists

Keywords: Kisspeptin 10 (human), Kisspeptin 10 (human) supplier, Endogenous, ligands, KISS1, receptors, hOT7T175/AXOR12/GPR54, Metastin, KISS-derived, Peptide, Kisspeptin10, (45-54), Kp-10, Kisspeptin, Receptor, 2570, Tocris Bioscience

5 Citations for Kisspeptin 10 (human)

Citations are publications that use Tocris products. Selected citations for Kisspeptin 10 (human) include:

Schwetz et al (2014) Differential stimulation of insulin secretion by GLP-1 and Kisspeptin-10. PLoS One 9 e113020 PMID: 25401335

Ji et al (2014) Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer. Autophagy 14 723 PMID: 25260785

Constantin and Wray (2016) Galanin Activates G Protein Gated Inwardly Rectifying Potassium Channels and Suppresses Kisspeptin-10 Activation of GnRH Neurons. Endocrinology 157 3197 PMID: 27359210

Wu et al (2012) Effects of kisspeptin-10 on lipid metabolism in cultured chicken hepatocytes. Asian-Australas J Anim Sci 25 1229 PMID: 25049685

Wu et al (2013) Kisspeptin-10 enhanced egg production in quails associated with the increase of triglyceride synthesis in liver. Asian-Australas J Anim Sci 26 1080 PMID: 25049888


Do you know of a great paper that uses Kisspeptin 10 (human) from Tocris? Please let us know.

Reviews for Kisspeptin 10 (human)

There are currently no reviews for this product. Be the first to review Kisspeptin 10 (human) and earn rewards!

Have you used Kisspeptin 10 (human)?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing