Kisspeptin 234

Pricing Availability Delivery Time Qty
Cat.No. 3881 - Kisspeptin 234 | Ac-D-Ala-Asn-Trp-Asn-Gly-Phe-Gly-D-Trp-Arg-Phe-NH2 | CAS No. 1145998-81-7
Description: Kisspeptin receptor antagonist; kisspeptin 10 (Cat. No. 2570) analog
Citations (2)

Biological Activity

kisspeptin receptor (KISS1, GPR54) antagonist; kisspeptin-10 (Cat. No. 2570) analog. Inhibits kisspeptin-10 stimulation of inositol phosphate (IP) (IC50 = 7 nM) and release of gonadotrophin-releasing hormone (GnRH).

Licensing Information

Sold under license

Technical Data

M. Wt 1295.42
Formula C63H78N18O13

(Modifications: Ala-1 = D-Ala & N-terminal Ac, Trp-8 = D-Trp, Phe-10 = C-terminal amide)

Storage Store at -20°C
CAS Number 1145998-81-7
PubChem ID 90488890
Smiles C[C@@H](NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1295.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.77 mL 3.86 mL 7.72 mL
5 mM 0.15 mL 0.77 mL 1.54 mL
10 mM 0.08 mL 0.39 mL 0.77 mL
50 mM 0.02 mL 0.08 mL 0.15 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Roseweir et al (2009) Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadototrophin regulation. J.Neurosci. 29 3920 PMID: 19321788

If you know of a relevant reference for Kisspeptin 234, please let us know.

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Keywords: Kisspeptin 234, supplier, KISS1, GPR54, antagonists, kisspeptin10, kisspeptin_10, analogs, analogues, Kisspeptin234, Kisspeptin, Receptor, Kisspeptin, Receptor, Tocris Bioscience

2 Citations for Kisspeptin 234

Citations are publications that use Tocris products. Selected citations for Kisspeptin 234 include:

Fayazi et al (2015) The pregnant mouse uterus exhibits a functional kisspeptin/KISS1R signaling system on the day of embryo implantation. Am J Physiol Renal Physiol 13 105 PMID: 26384646

Grachev et al (2012) GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. Reprod Biol Endocrinol 7 e44344 PMID: 23028524

Do you know of a great paper that uses Kisspeptin 234 from Tocris? If so please let us know.

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