Kisspeptin 234

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Description: Kisspeptin receptor antagonist; kisspeptin 10 (Cat. No. 2570) analog
Purity: ≥95% (HPLC)
Datasheet
Citations (4)
Reviews

Biological Activity for Kisspeptin 234

Kisspeptin 234 is a kisspeptin receptor (KISS1, GPR54) antagonist; kisspeptin-10 (Cat. No. 2570) analog. Inhibits kisspeptin-10 stimulation of inositol phosphate (IP) (IC50 = 7 nM) and release of gonadotrophin-releasing hormone (GnRH).

Licensing Information

Sold under license

Technical Data for Kisspeptin 234

M. Wt 1295.42
Formula C63H78N18O13
Sequence Ac-ANWNGFGWRF-NH2

(Modifications: Ala-1 = D-Ala & N-terminal Ac, Trp-8 = D-Trp, Phe-10 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1145998-81-7
PubChem ID 90488890
InChI Key IUPKBWSKNCAQJQ-JYYYXURSSA-N
Smiles C[C@@H](NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Kisspeptin 234

Solubility Soluble to 1 mg/ml in water

Product Datasheets for Kisspeptin 234

Certificate of Analysis / Product Datasheet
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References for Kisspeptin 234

References are publications that support the biological activity of the product.

Roseweir et al (2009) Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadototrophin regulation. J.Neurosci. 29 3920 PMID: 19321788


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Keywords: Kisspeptin 234, Kisspeptin 234 supplier, KISS1, GPR54, antagonists, kisspeptin10, kisspeptin_10, analogs, analogues, Kisspeptin234, Kisspeptin, Receptor, 3881, Tocris Bioscience

4 Citations for Kisspeptin 234

Citations are publications that use Tocris products. Selected citations for Kisspeptin 234 include:

Fayazi et al (2015) The pregnant mouse uterus exhibits a functional kisspeptin/KISS1R signaling system on the day of embryo implantation. Am J Physiol Renal Physiol 13 105 PMID: 26384646

Y S et al (2022) Kisspeptins inhibit human airway smooth muscle proliferation. JCI Insight 7 PMID: 35420998

Grachev et al (2012) GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. Reprod Biol Endocrinol 7 e44344 PMID: 23028524

Lei et al (2021) Kisspeptin-54 attenuates oxidative stress and neuronal apoptosis in early brain injury after subarachnoid hemorrhage in rats via GPR54/ARRB2/AKT/GSK3β signaling pathway. Free Radic Biol Med 171 99-111 PMID: 33989759


Do you know of a great paper that uses Kisspeptin 234 from Tocris? Please let us know.

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