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Submit ReviewKisspeptin 234
Description: Kisspeptin receptor antagonist; kisspeptin 10 (Cat. No. 2570) analog
Purity: ≥95% (HPLC)
Biological Activity for Kisspeptin 234
Kisspeptin 234 is a kisspeptin receptor (KISS1, GPR54) antagonist; kisspeptin-10 (Cat. No. 2570) analog. Inhibits kisspeptin-10 stimulation of inositol phosphate (IP) (IC50 = 7 nM) and release of gonadotrophin-releasing hormone (GnRH).
Licensing Information
Sold under license
Technical Data for Kisspeptin 234
| M. Wt | 1295.42 |
| Formula | C63H78N18O13 |
| Sequence |
Ac-ANWNGFGWRF-NH2 (Modifications: Ala-1 = D-Ala & N-terminal Ac, Trp-8 = D-Trp, Phe-10 = C-terminal amide) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 1145998-81-7 |
| PubChem ID | 90488890 |
| InChI Key | IUPKBWSKNCAQJQ-JYYYXURSSA-N |
| Smiles | C[C@@H](NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Kisspeptin 234
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Kisspeptin 234
References for Kisspeptin 234
References are publications that support the biological activity of the product.
Roseweir et al (2009) Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadototrophin regulation. J.Neurosci. 29 3920 PMID: 19321788
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Keywords: Kisspeptin 234, Kisspeptin 234 supplier, KISS1, GPR54, antagonists, kisspeptin10, kisspeptin_10, analogs, analogues, Kisspeptin234, Kisspeptin, Receptor, 3881, Tocris Bioscience
4 Citations for Kisspeptin 234
Citations are publications that use Tocris products. Selected citations for Kisspeptin 234 include:
Lei et al (2021) Kisspeptin-54 attenuates oxidative stress and neuronal apoptosis in early brain injury after subarachnoid hemorrhage in rats via GPR54/ARRB2/AKT/GSK3β signaling pathway. Free Radic Biol Med 171 99-111 PMID: 33989759
Grachev et al (2012) GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. Reprod Biol Endocrinol 7 e44344 PMID: 23028524
Fayazi et al (2015) The pregnant mouse uterus exhibits a functional kisspeptin/KISS1R signaling system on the day of embryo implantation. Am J Physiol Renal Physiol 13 105 PMID: 26384646
Y S et al (2022) Kisspeptins inhibit human airway smooth muscle proliferation. JCI Insight 7 PMID: 35420998
Do you know of a great paper that uses Kisspeptin 234 from Tocris? Please let us know.
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