ITK

ITK (IL-2-inducible T-cell kinase) is a member of the Tec family of nonreceptor tyrosine kinases that are critically important for the growth, differentiation and activation of myeloid-, mast- and B-cells. ITK has a critical role in T-cell growth, signaling and function.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
5009 BMS 509744
Potent and selective ITK inhibitor
4726 CTA 056
ITK inhibitor
5401 GSK 2250665A
Itk inhibitor
4710 PF 06465469
Potent ITK inhibitor; also inhibits BTK

ITK (IL-2-inducible T-cell kinase) EC 2.7.10.2 is a member of the Tec family of nonreceptor tyrosine kinases, which includes Bruton's tyrosine kinase. It is critical for the growth, differentiation and activation of T-cells. ITK is expressed in T-lymphocytes and acts downstream from T-cell receptor (TCR) stimulation. Activation of PI 3-kinase results in the accumulation of PIP3, which in turn leads to the recruitment of ITK to the membrane, its activation and subsequent autophosphorylation. Activated ITK interacts with and phosphorylates PLCγ, eventually leading to Ca2+ mobilization, transcription, cytokine release and actin reorganization.

ITK signaling is important in the protective response of the Th2 effector cells to infection, mediating the secretion of interleukins 4, 5, 10 and 13. The enzyme also has a role in the production of IL-17A by Th17 cells, which is essential for antimicrobial activity as well as being involved in autoimmune disorders. ITK is a target for research in multiple sclerosis, cancer (both hematological malignancies and solid tumors) and graft versus host disease.

External sources of pharmacological information for ITK :

    Literature for ITK

    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Immunology

    Immunology Product Listing

    A collection of over 190 products for immunology research, the guide includes research tools for the study of:

    • Chemokine and Cytokine Signaling
    • Chemotaxis
    • Complement System
    • Immune Cell Signaling
    • Inflammation
    Kinases

    Kinases Product Listing

    A collection of over 400 products for kinase research, the listing includes inhibitors of:

    • Receptor Tyrosine Kinases
    • Protein Kinases A, C, D and G
    • PI-3 Kinase, Akt and mTOR
    • MAPK Signaling
    • Receptor Serine/Threonine Kinases

    ITK Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    ITK Human ITK NM_005546 Q08881
    Mouse Itk NM_001281965 Q03526
    Rat Itk NM_001108825 NP_001102295