CTA 056

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Description: ITK inhibitor
Chemical Name: 1,5-Dihydro-7-(phenylmethyl)-1-[3-(1-piperidinyl)propyl]-2-[4-(4-pyridinyl)phenyl]-6H-imidazo[4,5-g]quinoxalin-6-one
Purity: ≥98% (HPLC)
Citations (1)
Reviews (1)

Biological Activity for CTA 056

CTA 056 is an interleukin-2-inducible T-cell kinase (ITK) inhibitor (IC50 values are 0.1, 0.4 and 5 μM for ITK, BTK and ETK, respectively). Inhibits growth of cancer cells expressing ITK, including MOLT-4 and Jurkat cells in vitro. Induces apoptosis in Jurkat cells. Inhibits MOLT-4 xenograft tumor growth in mice.

Technical Data for CTA 056

M. Wt 554.68
Formula C35H34N6O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1265822-30-7
PubChem ID 49870925
Smiles O=C2C(CC7=CC=CC=C7)=NC1=CC3=C(N=C(C5=CC=C(C6=CC=NC=C6)C=C5)N3CCCN4CCCCC4)C=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CTA 056

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.55 10 with gentle warming

Preparing Stock Solutions for CTA 056

The following data is based on the product molecular weight 554.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.03 mL 90.14 mL 180.28 mL
0.5 mM 3.61 mL 18.03 mL 36.06 mL
1 mM 1.8 mL 9.01 mL 18.03 mL
5 mM 0.36 mL 1.8 mL 3.61 mL

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References for CTA 056

References are publications that support the biological activity of the product.

Guo et al (2012) Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs. Mol.Pharmacol. 82 938 PMID: 22899868

If you know of a relevant reference for CTA 056, please let us know.

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Keywords: CTA 056, CTA 056 supplier, CTA056, cancer, apoptosis, interleukin, 2, inducible, T-cell, kinase, Itk, inhibitors, inhibits, induces, inducers, ITK, 4726, Tocris Bioscience

1 Citation for CTA 056

Citations are publications that use Tocris products. Selected citations for CTA 056 include:

Mues et al (2019) High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions. Cell Rep 27 631 PMID: 30970263

Do you know of a great paper that uses CTA 056 from Tocris? Please let us know.

Reviews for CTA 056

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T-ALL Network and Pharmacological Validation of Synthetic Lethal Screen.
By Anonymous on 03/26/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: T cell line


PMID: 30970263
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