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Interleukin-2-inducible T-cell kinase (ITK) inhibitor (IC50 values are 0.1, 0.4 and 5 μM for ITK, BTK and ETK, respectively). Inhibits growth of cancer cells expressing ITK, including MOLT-4 and Jurkat cells in vitro. Induces apoptosis in Jurkat cells. Inhibits MOLT-4 xenograft tumor growth in mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|DMSO||5.55||10 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 554.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||18.03 mL||90.14 mL||180.28 mL|
|0.5 mM||3.61 mL||18.03 mL||36.06 mL|
|1 mM||1.8 mL||9.01 mL||18.03 mL|
|5 mM||0.36 mL||1.8 mL||3.61 mL|
References are publications that support the biological activity of the product.
Guo et al (2012) Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs. Mol.Pharmacol. 82 938 PMID: 22899868
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Keywords: CTA 056, CTA 056 supplier, CTA056, cancer, apoptosis, interleukin, 2, inducible, T-cell, kinase, Itk, inhibitors, inhibits, induces, inducers, ITK, 4726, Tocris Bioscience
1 Citation for CTA 056
Citations are publications that use Tocris products. Selected citations for CTA 056 include:
Mues et al (2019) High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions. Cell Rep 27 631 PMID: 30970263
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