CTA 056

Pricing Availability   Qty
Cat.No. 4726 - CTA 056 | CAS No. 1265822-30-7
Description: ITK inhibitor
Chemical Name: 1,5-Dihydro-7-(phenylmethyl)-1-[3-(1-piperidinyl)propyl]-2-[4-(4-pyridinyl)phenyl]-6H-imidazo[4,5-g]quinoxalin-6-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Interleukin-2-inducible T-cell kinase (ITK) inhibitor (IC50 values are 0.1, 0.4 and 5 μM for ITK, BTK and ETK, respectively). Inhibits growth of cancer cells expressing ITK, including MOLT-4 and Jurkat cells in vitro. Induces apoptosis in Jurkat cells. Inhibits MOLT-4 xenograft tumor growth in mice.

Technical Data

M. Wt 554.68
Formula C35H34N6O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1265822-30-7
PubChem ID 49870925
InChI Key BSSBAJKNZOHHCA-UHFFFAOYSA-N
Smiles O=C2C(CC7=CC=CC=C7)=NC1=CC3=C(N=C(C5=CC=C(C6=CC=NC=C6)C=C5)N3CCCN4CCCCC4)C=C1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.55 10 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 554.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.03 mL 90.14 mL 180.28 mL
0.5 mM 3.61 mL 18.03 mL 36.06 mL
1 mM 1.8 mL 9.01 mL 18.03 mL
5 mM 0.36 mL 1.8 mL 3.61 mL

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References

References are publications that support the biological activity of the product.

Guo et al (2012) Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs. Mol.Pharmacol. 82 938 PMID: 22899868


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Keywords: CTA 056, CTA 056 supplier, CTA056, cancer, apoptosis, interleukin, 2, inducible, T-cell, kinase, Itk, inhibitors, inhibits, induces, inducers, ITK, 4726, Tocris Bioscience

Citations for CTA 056

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Literature in this Area

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