Cdc2-like Kinases

CLKs (Cdc2-like kinase) are dual specificity protein kinases which are involved in gene splicing regulation. The CLK family has four family members: CLK1/STY, CLK2, CLK3 and CLK4. CLKs are useful targets for studying diseases attributed to gene mis-splicing events.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
5700 ML 315 hydrochloride
Inhibitor of Clk and DYRK kinases
4336 TG 003
Potent inhibitor of Clk-family kinases; also inhibits DYRK1A/B

Related Targets

    The CLK (Cdc2-like kinase) family has four family members: CLK1/STY, CLK2, CLK3 and CLK4. CLKs are dual specificity protein kinases which are self-activated through autophosphorylation on tyrosine residues and phosphorylate their substrates on serine and threonine residues. All family members have N-terminal domains which are rich in serine and arginine residues. They also have a conserved EHLAMMERRIG sequence in the catalytic domain and are thus also known as LAMMER kinases.

    Mammalian CLK families contain a SR domain which has been shown to phosphorylate serine/arginine-rich (SR) proteins in vitro and phosphorylate SR protein ASF/SF2 in vivo. This phosphorylation modulates gene splicing and consequently gene expression. CLKs may also modulate the intranuclear distribution of SR proteins, adding a further layer of complexity to the control of gene splicing.

    Furthermore, phosphorylation of SR proteins affects their protein-protein interactions, protein-RNA interactions, intracellular localization and trafficking, as well as their alternative splicing of pre-mRNA. In addition, CLKs are useful targets for studying diseases attributed to mis-splicing events as well as conditions such as muscular dystrophy and HIV.

    External sources of pharmacological information for Cdc2-like Kinases :

      Literature for Cdc2-like Kinases

      Kinases

      Kinases Product Listing

      A collection of over 400 products for kinase research, the listing includes inhibitors of:

      • Receptor Tyrosine Kinases
      • Protein Kinases A, C, D and G
      • PI-3 Kinase, Akt and mTOR
      • MAPK Signaling
      • Receptor Serine/Threonine Kinases

      Cdc2-like Kinases Gene Data

      Gene Species Gene Symbol Gene Accession No. Protein Accession No.
      CLK1 Human CLK1 NM_004071 P49759
      Mouse Clk1 NM_001042634 NM_001042634
      Rat Clk1 NM_001106913 NP_001100383
      CLK2 Human CLK2 NM_003993 P49760
      Mouse Clk2 NM_007712 O35491
      Rat Clk2 NM_001014254 NP_001014276
      CLK3 Human CLK3 NM_003992 P49761
      Mouse Clk3 NM_007713 O35492
      Rat Clk3 NM_134340 NP_599167
      CLK4 Human CLK4 NM_020666 Q9HAZ1
      Mouse Clk4 NM_007714 O35493
      Rat Clk4 NM_001013041 NP_001013059