T3 CLK

Pricing Availability   Qty
Description: Potent and selective pan-CLK inhibitor; also inhibits DYRK1A/B
Chemical Name: 4-[1,1-Dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for T3 CLK

T3 CLK is a potent and selective pan CDC-like kinase (CLK) inhibitor (IC50 values are 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively). T3 CLK also inhibits DYRK1A/B (IC50 values are 230 nM and 260 nM for DYRK1B and DYRK1A, respectively in cellular assays). Exhibits dose-dependent alternative splicing effects in HCT116 colorectal cancer cells. T3 CLK is cell permeable, stable and non-toxic.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the T3 CLK probe summary on the SGC website.

Technical Data for T3 CLK

M. Wt 482.58
Formula C28H30N6O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2109805-56-1
PubChem ID 132585205
InChI Key IEFFSHLHNYVSEF-UHFFFAOYSA-N
Smiles O=C(NC=1N=C2C=CC(=CN2C1)C=3C=CN=CC3)C4=CC=C(C=C4)C(C(=O)N5CCN(C)CC5)(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for T3 CLK

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.13 50 with gentle warming
ethanol 4.83 10 with gentle warming

Preparing Stock Solutions for T3 CLK

The following data is based on the product molecular weight 482.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.14 mL 20.72 mL 41.44 mL
2.5 mM 0.83 mL 4.14 mL 8.29 mL
5 mM 0.41 mL 2.07 mL 4.14 mL
25 mM 0.08 mL 0.41 mL 0.83 mL

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References for T3 CLK

References are publications that support the biological activity of the product.

Funnell et al (2017) CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor. Nat.Commun. 8 7 PMID: 28232751


If you know of a relevant reference for T3 CLK, please let us know.

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Citations for T3 CLK

Citations are publications that use Tocris products.

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