ML 315 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 5700 - ML 315 hydrochloride | C18H13Cl2N3O2.HCl | CAS No. 1440251-53-5
Description: Inhibitor of Clk and DYRK kinases
Chemical Name: 5-(1,3-Benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]-4-pyrimidinamine hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

Inhibitor of cdc2-like kinases (Clk) and DYRK kinases (IC50 values are 68, 68 and 231 nM for Clk1, Clk4 and Clk2, respectively, and 282 and 1156 nM for Dyrk1A and Dyrk1B). Shows 20-fold selectivity for Clk4 over Dyrk1A. Stable in both mouse and human plasma. Moderately cell permeable.

Technical Data

M. Wt 410.68
Formula C18H13Cl2N3O2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1440251-53-5
PubChem ID 127021037
Smiles ClC1=CC(CNC2=NC=NC=C2C3=CC=C(OCO4)C4=C3)=CC(Cl)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.42 100
ethanol 18.71 50

Preparing Stock Solutions

The following data is based on the product molecular weight 410.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.17 mL 24.35 mL
5 mM 0.49 mL 2.43 mL 4.87 mL
10 mM 0.24 mL 1.22 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Coombs et al (2013) Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg.Med.Chem.Lett. 23 3654 PMID: 23642479

If you know of a relevant reference for ML 315 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Cdc2-like Kinase Inhibitors

Keywords: ML 315 hydrochloride, supplier, ML315, HCl, Inhibitors, Inhibits, Cdc2-like, kinases, Clk, kinase, Dual, specificity, tyrosine, phosphorylation-regulated, kinases, DYRK, kinase, Cdc2-like, kinases, DYRK, Cdc2-like, kinases, Tocris Bioscience

Citations for ML 315 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for ML 315 hydrochloride. Do you know of a great paper that uses ML 315 hydrochloride from Tocris? If so please let us know.

ML 315 hydrochloride Reviews

Average Rating:

(Based on 0 Reviews)

1 Star
2 Star
3 Star
4 Star
5 Star

Have you used ML 315 hydrochloride?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Literature in this Area


Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases