ML 315 hydrochloride

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Cat.No. 5700 - ML 315 hydrochloride | C18H13Cl2N3O2.HCl | CAS No. 1440251-53-5
Description: Inhibitor of Clk and DYRK kinases
Chemical Name: 5-(1,3-Benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]-4-pyrimidinamine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Inhibitor of cdc2-like kinases (Clk) and DYRK kinases (IC50 values are 68, 68 and 231 nM for Clk1, Clk4 and Clk2, respectively, and 282 and 1156 nM for Dyrk1A and Dyrk1B). Shows 20-fold selectivity for Clk4 over Dyrk1A. Stable in both mouse and human plasma. Moderately cell permeable.

Technical Data

M. Wt 410.68
Formula C18H13Cl2N3O2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1440251-53-5
PubChem ID 127021037
InChI Key MNCDEAAKKQCKSX-UHFFFAOYSA-N
Smiles ClC1=CC(CNC2=NC=NC=C2C3=CC=C(OCO4)C4=C3)=CC(Cl)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.42 100
ethanol 18.71 50

Preparing Stock Solutions

The following data is based on the product molecular weight 410.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.17 mL 24.35 mL
5 mM 0.49 mL 2.43 mL 4.87 mL
10 mM 0.24 mL 1.22 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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References

References are publications that support the biological activity of the product.

Coombs et al (2013) Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg.Med.Chem.Lett. 23 3654 PMID: 23642479


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Literature in this Area

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Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases