TG 003

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Cat.No. 4336 - TG 003 | C13H15NO2S | CAS No. 719277-26-6
Description: Potent inhibitor of Clk-family kinases; also inhibits DYRK1A/B
Chemical Name: (1Z)-1-(3-Ethyl-5-methoxy-2(3H)-benzothiazolylidene)-2-propanone
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent, ATP-competitive inhibitor of Clk-family kinases (IC50 values are 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μM for mClk3). Also inhibits DYRK1A/B (IC50 values are 24 and 34 nM respectively). Suppresses serine/arginine-rich protein phosphorylation; affects the regulation of alternative splicing by phosphorylation of SR protein both in vitro and in vivo.

Technical Data

M. Wt 249.33
Formula C13H15NO2S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 719277-26-6
PubChem ID 647991
InChI Key BGVLELSCIHASRV-UHFFFAOYSA-N
Smiles O=C(C)/C=C1SC2=CC=C(OC)C=C2N\1CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.93 100
ethanol 18.7 75

Preparing Stock Solutions

The following data is based on the product molecular weight 249.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.01 mL 20.05 mL 40.11 mL
5 mM 0.8 mL 4.01 mL 8.02 mL
10 mM 0.4 mL 2.01 mL 4.01 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Muraki et al (2004) Manipulation of alternative splicing by a newly developed inhibitor of Clks. J.Biol.Chem. 279 24246 PMID: 15010457

Foucourt et al (2014) Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part II. Molecules 19 15411 PMID: 25264830


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View all Cdc2-like Kinase Inhibitors

Keywords: TG003 ATP-competitive Cdc2-like inhibitors inhibits Clk Clk-family kinases DYRK1A DYRK1B DYRK1A/B Cdc2-like kinases

Citations for TG 003

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Literature in this Area

Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases

Pathways for TG 003

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