C28

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: Potent LMTK3 inhibitor
Chemical Name: 6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for C28

C28 is a potent lemur tyrosine kinase 3 (LMTK3) inhibitor (IC50 = 67 nM). Disrupts interaction of LMTK3 and HSP90 leading to degradation of LMTK3. Also inhibits CLK, DYRK1α, IRAK4 and HIPK2 (IC50 values are 5 nM, 6 nM, 41 nM and 48 nM respectively). C28 inhibits growth and increases apoptosis in breast cancer cell lines (IC50 = 6.5-14.77 μM) and reduces growth of tumors in xenograft and transgenic mouse models of breast cancer. Also reduces levels of ERα.

Licensing Information

Sold with kind permission of the Giamas lab, University of Sussex

Technical Data for C28

M. Wt 356.31
Formula C18H11F3N4O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2764850-23-7
PubChem ID 138454301
InChI Key SFBZOJORTROAIE-UHFFFAOYSA-N
Smiles FC(F)(OC1=CC(C2=CN=C3C=CC(C4=CC=NC=C4)=NN32)=CC=C1)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for C28

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.82 50
ethanol 7.13 20

Preparing Stock Solutions for C28

The following data is based on the product molecular weight 356.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.61 mL 28.07 mL 56.13 mL
2.5 mM 1.12 mL 5.61 mL 11.23 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
25 mM 0.11 mL 0.56 mL 1.12 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for C28

References are publications that support the biological activity of the product.

Ditsiou et al (2020) The structure-function relationship of oncogenic LMTK3. Sci.Adv. 6 eabc3099 PMID: 33188023


If you know of a relevant reference for C28, please let us know.

View Related Products by Target

Keywords: C28, C28 supplier, LMTK3, lemur, tyrosine, kinase, inhibitors, inhibits, potent, kinases, tumor, apoptosis, ER, breast, cancer, hsp90, CLK, DYRK1alpha, Other, Kinases, (Cdc2-like, kinases), DYRK, IRAK, 7546, Tocris Bioscience

Citations for C28

Citations are publications that use Tocris products.

Currently there are no citations for C28. Do you know of a great paper that uses C28 from Tocris? Please let us know.

Reviews for C28

There are currently no reviews for this product. Be the first to review C28 and earn rewards!

Have you used C28?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review