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Description: Potent LMTK3 inhibitor
Chemical Name: 6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine
Purity: ≥98% (HPLC)

Biological Activity for C28

C28 is a potent lemur tyrosine kinase 3 (LMTK3) inhibitor (IC50 = 67 nM). Disrupts interaction of LMTK3 and HSP90 leading to degradation of LMTK3. Also inhibits CLK, DYRK1α, IRAK4 and HIPK2 (IC50 values are 5 nM, 6 nM, 41 nM and 48 nM respectively). C28 inhibits growth and increases apoptosis in breast cancer cell lines (IC50 = 6.5-14.77 μM) and reduces growth of tumors in xenograft and transgenic mouse models of breast cancer. Also reduces levels of ERα.

Licensing Information

Sold with kind permission of the Giamas lab, University of Sussex

Technical Data for C28

M. Wt 356.31
Formula C18H11F3N4O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2764850-23-7
PubChem ID 138454301
Smiles FC(F)(OC1=CC(C2=CN=C3C=CC(C4=CC=NC=C4)=NN32)=CC=C1)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for C28

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.82 50
ethanol 7.13 20

Preparing Stock Solutions for C28

The following data is based on the product molecular weight 356.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.61 mL 28.07 mL 56.13 mL
2.5 mM 1.12 mL 5.61 mL 11.23 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
25 mM 0.11 mL 0.56 mL 1.12 mL

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References for C28

References are publications that support the biological activity of the product.

Ditsiou et al (2020) The structure-function relationship of oncogenic LMTK3. Sci.Adv. 6 eabc3099 PMID: 33188023

If you know of a relevant reference for C28, please let us know.

View Related Products by Target

Keywords: C28, C28 supplier, LMTK3, lemur, tyrosine, kinase, inhibitors, inhibits, potent, kinases, tumor, apoptosis, ER, breast, cancer, hsp90, CLK, DYRK1alpha, Other, Kinases, (Cdc2-like, kinases), DYRK, IRAK, 7546, Tocris Bioscience

Citations for C28

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