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Biological Activity for C28
C28 is a potent lemur tyrosine kinase 3 (LMTK3) inhibitor (IC50 = 67 nM). Disrupts interaction of LMTK3 and HSP90 leading to degradation of LMTK3. Also inhibits CLK, DYRK1α, IRAK4 and HIPK2 (IC50 values are 5 nM, 6 nM, 41 nM and 48 nM respectively). C28 inhibits growth and increases apoptosis in breast cancer cell lines (IC50 = 6.5-14.77 μM) and reduces growth of tumors in xenograft and transgenic mouse models of breast cancer. Also reduces levels of ERα.
Sold with kind permission of the Giamas lab, University of Sussex
Technical Data for C28
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for C28
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for C28
The following data is based on the product molecular weight 356.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.61 mL||28.07 mL||56.13 mL|
|2.5 mM||1.12 mL||5.61 mL||11.23 mL|
|5 mM||0.56 mL||2.81 mL||5.61 mL|
|25 mM||0.11 mL||0.56 mL||1.12 mL|
References for C28
References are publications that support the biological activity of the product.
Ditsiou et al (2020) The structure-function relationship of oncogenic LMTK3. Sci.Adv. 6 eabc3099 PMID: 33188023
If you know of a relevant reference for C28, please let us know.
Keywords: C28, C28 supplier, LMTK3, lemur, tyrosine, kinase, inhibitors, inhibits, potent, kinases, tumor, apoptosis, ER, breast, cancer, hsp90, CLK, DYRK1alpha, Other, Kinases, (Cdc2-like, kinases), DYRK, IRAK, 7546, Tocris Bioscience
Citations for C28
Citations are publications that use Tocris products.
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Reviews for C28
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Literature in this Area
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