Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
C28 is a potent lemur tyrosine kinase 3 (LMTK3) inhibitor (IC50 = 67 nM). Disrupts interaction of LMTK3 and HSP90 leading to degradation of LMTK3. Also inhibits CLK, DYRK1α, IRAK4 and HIPK2 (IC50 values are 5 nM, 6 nM, 41 nM and 48 nM respectively). C28 inhibits growth and increases apoptosis in breast cancer cell lines (IC50 = 6.5-14.77 μM) and reduces growth of tumors in xenograft and transgenic mouse models of breast cancer. Also reduces levels of ERα.
Sold with kind permission of the Giamas lab, University of Sussex
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 356.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.61 mL||28.07 mL||56.13 mL|
|2.5 mM||1.12 mL||5.61 mL||11.23 mL|
|5 mM||0.56 mL||2.81 mL||5.61 mL|
|25 mM||0.11 mL||0.56 mL||1.12 mL|
References are publications that support the biological activity of the product.
Ditsiou et al (2020) The structure-function relationship of oncogenic LMTK3. Sci.Adv. 6 eabc3099 PMID: 33188023
If you know of a relevant reference for C28, please let us know.
Keywords: C28, C28 supplier, LMTK3, lemur, tyrosine, kinase, inhibitors, inhibits, potent, kinases, tumor, apoptosis, ER, breast, cancer, hsp90, CLK, DYRK1alpha, Other, Kinases, (Cdc2-like, kinases), DYRK, IRAK, 7546, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for C28. Do you know of a great paper that uses C28 from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review C28 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.