Carbonic Anhydrases

Carbonic anhydrases (EC 4.2.1.1) are zinc-containing enzymes belonging to the lyases family, and are primarily responsible for catalyzing the reversible hydration of carbon dioxide to form bicarbonate (HCO3-) and hydrogen (H+) ions.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
5577 S4
High affinity and selective CA IX and CA XII inhibitor
3620 Topiramate
GluR5 antagonist; inhibits carbonic anhydrase (CA) II and IV
4540 U 104
Potent carbonic anhydrase (CA) IX and XII inhibitor

Related Targets

    Carbonic anhydrases (EC 4.2.1.1) are zinc-containing enzymes belonging to the lyases family, and are primarily responsible for catalyzing the reversible hydration of carbon dioxide to form bicarbonate (HCO3-) and hydrogen (H+) ions.

    There are several different carbonic anhydrase isoforms; these can be broadly grouped into cytosolic (CA I, CA II, CA III, CA VII, CA XIII), mitochondrial (CA VA, CA VB), secreted (CA VI) and membrane-associated (CA IV, CA IX, CA XII, CA XIV) carbonic anhydrases. The functions of the remaining carbonic anhydrases are yet to be elucidated.

    Expression of the membrane-bound carbonic anhydrase, CA IX, has been reported in hypoxic tumors where its activity is linked to promoting survival of tumor cells and aiding cancer progression. This is thought to occur through the carbonic anhydrase-mediated production of bicarbonate ions, which neutralizes the abnormally acidic pH of the extracellular environment induced during hypoxia. Furthermore, as CA IX is a hypoxia- and HIF-1-inducible enzyme, its expression can be used as a biomarker for hypoxic tumors.

    Literature for Carbonic Anhydrases

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    Carbonic anhydrase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    Carbonic anhydrase I Human CA1 NM_001738 P00915
    Mouse Car1 NM_009799 P13634
    Rat Car1 NM_00107660 B0BNN3
    Carbonic anhydrase II Human CA2 NM_000067 P00918
    Mouse Car2 NM_009801 P00920
    Rat Car2 NM_019291 P27139
    Carbonic anhydrase III Human CA3 NM_005181 P07451
    Mouse Car3 NM_007606 P16015
    Rat Car3 NM_019174 P48284
    Carbonic anhydrase IV Human CA4 NM_000717 P22748
    Mouse Car4 NM_007607 Q64444
    Rat Car4 NM_019174 P48284
    Carbonic anhydrase VA, mitochondrial Human CA5A NM_001739 P35218
    Mouse Car5a NM_007607 Q64444
    Rat Car5a NM_019293 P43165
    Carbonic anhydrase VB, mitochondrial Human CA5B NM_007220 Q9Y2D0
    Mouse Car5b NM_181315 Q9QZA0
    Rat Car5b NM_001005551 Q66HG6
    Carbonic anhydrase VI Human CA6 NM_001215 P23280
    Mouse Car6 NM_009802 P18761
    Rat Car6 NM_001134841 Q3HS81
    Carbonic anhydrase VII Human CA7 NM_001014435 P43166
    Mouse Car7 NM_053070 Q9ERQ8
    Rat Car7 NM_001106165 B2RZ61
    Carbonic anhydrase VIII Human CA8 NM_004056 P35219
    Mouse Car8 NM_007592 P28651
    Rat Car8 NM_001009662 Q5PPN4
    Carbonic anhydrase IX Human CA9 NM_001216 Q16790
    Mouse Car9 NM_139305 Q8VHB5
    Rat Car9 NM_001107956 A2IBE1
    Carbonic anhydrase X Human CA10 NM_020178 Q9NS85
    Mouse Car10 NM_028296 P61215
    Rat - - -
    Carbonic anhydrase XI Human CA11 NM_001217 O75493
    Mouse Car11 NM_009800 O70354
    Rat Car11 NM_175708 Q811X3
    Carbonic anhydrase XII Human CA12 NM_001218 O43570
    Mouse Car12 NM_178396 Q8CI85
    Rat Car12 NM_001080756 Q58HA5
    Carbonic anhydrase XIII Human CA13 NM_198584 Q8N1Q1
    Mouse Car13 NM_024495 Q9D6N1
    Rat Car13 NM_001134993 B5DFG6
    Carbonic anhydrase XIV Human CA14 NM_012113 Q9ULX7
    Mouse Car14 NM_011797 Q9WVT6
    Rat Car14 NM_001109655 A2IBE0