Carbonic Anhydrases

Carbonic anhydrases (EC 4.2.1.1) are zinc-containing enzymes belonging to the lyases family, and are primarily responsible for catalyzing the reversible hydration of carbon dioxide to form bicarbonate (HCO3-) and hydrogen (H+) ions.

Products
Background
Literature (1)
Gene Data

Inhibitors

Cat. No. Product Name / Activity
6742 Acetazolamide
Carbonic anhydrase inhibitor
6782 Indisulam
High affinity carbonic anhydrase isozyme XII (hCA XII) inhibitor; pre-mRNA splicing modulator
5577 S4
High affinity and selective CA IX and CA XII inhibitor
3620 Topiramate
Inhibits carbonic anhydrase (CA) II and IV; GluK1 antagonist; also positive allosteric modulator of GABAA receptors
4540 U 104
Potent carbonic anhydrase (CA) IX and XII inhibitor

Related Targets

    Carbonic anhydrases (EC 4.2.1.1) are zinc-containing enzymes belonging to the lyases family, and are primarily responsible for catalyzing the reversible hydration of carbon dioxide to form bicarbonate (HCO3-) and hydrogen (H+) ions.

    There are several different carbonic anhydrase isoforms; these can be broadly grouped into cytosolic (CA I, CA II, CA III, CA VII, CA XIII), mitochondrial (CA VA, CA VB), secreted (CA VI) and membrane-associated (CA IV, CA IX, CA XII, CA XIV) carbonic anhydrases. The functions of the remaining carbonic anhydrases are yet to be elucidated.

    Expression of the membrane-bound carbonic anhydrase, CA IX, has been reported in hypoxic tumors where its activity is linked to promoting survival of tumor cells and aiding cancer progression. This is thought to occur through the carbonic anhydrase-mediated production of bicarbonate ions, which neutralizes the abnormally acidic pH of the extracellular environment induced during hypoxia. Furthermore, as CA IX is a hypoxia- and HIF-1-inducible enzyme, its expression can be used as a biomarker for hypoxic tumors.

    External sources of pharmacological information for Carbonic Anhydrases :

      Literature for Carbonic Anhydrases

      Tocris offers the following scientific literature for Carbonic Anhydrases to showcase our products. We invite you to request* or download your copy today!

      *Please note that Tocris will only send literature to established scientific business / institute addresses.


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      Carbonic anhydrase Gene Data

      Gene Species Gene Symbol Gene Accession No. Protein Accession No.
      Carbonic anhydrase I Human CA1 NM_001738 P00915
      Mouse Car1 NM_009799 P13634
      Rat Car1 NM_00107660 B0BNN3
      Carbonic anhydrase II Human CA2 NM_000067 P00918
      Mouse Car2 NM_009801 P00920
      Rat Car2 NM_019291 P27139
      Carbonic anhydrase III Human CA3 NM_005181 P07451
      Mouse Car3 NM_007606 P16015
      Rat Car3 NM_019174 P48284
      Carbonic anhydrase IV Human CA4 NM_000717 P22748
      Mouse Car4 NM_007607 Q64444
      Rat Car4 NM_019174 P48284
      Carbonic anhydrase VA, mitochondrial Human CA5A NM_001739 P35218
      Mouse Car5a NM_007607 Q64444
      Rat Car5a NM_019293 P43165
      Carbonic anhydrase VB, mitochondrial Human CA5B NM_007220 Q9Y2D0
      Mouse Car5b NM_181315 Q9QZA0
      Rat Car5b NM_001005551 Q66HG6
      Carbonic anhydrase VI Human CA6 NM_001215 P23280
      Mouse Car6 NM_009802 P18761
      Rat Car6 NM_001134841 Q3HS81
      Carbonic anhydrase VII Human CA7 NM_001014435 P43166
      Mouse Car7 NM_053070 Q9ERQ8
      Rat Car7 NM_001106165 B2RZ61
      Carbonic anhydrase VIII Human CA8 NM_004056 P35219
      Mouse Car8 NM_007592 P28651
      Rat Car8 NM_001009662 Q5PPN4
      Carbonic anhydrase IX Human CA9 NM_001216 Q16790
      Mouse Car9 NM_139305 Q8VHB5
      Rat Car9 NM_001107956 A2IBE1
      Carbonic anhydrase X Human CA10 NM_020178 Q9NS85
      Mouse Car10 NM_028296 P61215
      Rat - - -
      Carbonic anhydrase XI Human CA11 NM_001217 O75493
      Mouse Car11 NM_009800 O70354
      Rat Car11 NM_175708 Q811X3
      Carbonic anhydrase XII Human CA12 NM_001218 O43570
      Mouse Car12 NM_178396 Q8CI85
      Rat Car12 NM_001080756 Q58HA5
      Carbonic anhydrase XIII Human CA13 NM_198584 Q8N1Q1
      Mouse Car13 NM_024495 Q9D6N1
      Rat Car13 NM_001134993 B5DFG6
      Carbonic anhydrase XIV Human CA14 NM_012113 Q9ULX7
      Mouse Car14 NM_011797 Q9WVT6
      Rat Car14 NM_001109655 A2IBE0