S4

Pricing Availability Delivery Time Qty
Cat.No. 5577 - S4 | C15H17N3O4S | CAS No. 1330061-67-0
Description: High affinity and selective CA IX and CA XII inhibitor
Chemical Name: 4-[[[(3,5-Dimethylphenyl)amino]carbonyl]amino]phenyl sulfamate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity and selective CA IX and CA XII inhibitor (Ki values are 2, 7, 547 and 5600 nM for CA XII, IX, II andI, respectively). Inhibits migration and proliferation of breast cancer cells in vitro. Inhibits lung metastasis in mice bearing breast tumor xenografts, without affecting primary tumor.

Compound Libraries

S4 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 335.38
Formula C15H17N3O4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1330061-67-0
PubChem ID 53342705
InChI Key HGVHSNXRZYOTPD-UHFFFAOYSA-N
Smiles NS(OC1=CC=C(NC(NC2=CC(C)=CC(C)=C2)=O)C=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.54 100
ethanol 6.71 20

Preparing Stock Solutions

The following data is based on the product molecular weight 335.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.98 mL 14.91 mL 29.82 mL
5 mM 0.6 mL 2.98 mL 5.96 mL
10 mM 0.3 mL 1.49 mL 2.98 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Gieling et al (2012) Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J.Med.Chem. 55 5591 PMID: 22621623


If you know of a relevant reference for S4, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Carbonic Anhydrase Inhibitors

Keywords: carbonic anhydrase IX XII high affinity selective inhibitors inhibits metastasis migration cancer antimetastatic Carbonic anhydrases

Citations for S4

Citations are publications that use Tocris products.

Currently there are no citations for S4. Do you know of a great paper that uses S4 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for S4

Protocols

TODO: Add Protocols