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Description: High affinity and selective CA IX and CA XII inhibitor
Chemical Name: 4-[[[(3,5-Dimethylphenyl)amino]carbonyl]amino]phenyl sulfamate
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for S4

S4 is a high affinity and selective CA IX and CA XII inhibitor (Ki values are 2, 7, 547 and 5600 nM for CA XII, IX, II and I, respectively). Inhibits migration and proliferation of breast cancer cells in vitro. Inhibits lung metastasis in mice bearing breast tumor xenografts, without affecting primary tumor.

Compound Libraries for S4

S4 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for S4

M. Wt 335.38
Formula C15H17N3O4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1330061-67-0
PubChem ID 53342705
Smiles NS(OC1=CC=C(NC(NC2=CC(C)=CC(C)=C2)=O)C=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for S4

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.54 100
ethanol 6.71 20

Preparing Stock Solutions for S4

The following data is based on the product molecular weight 335.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.98 mL 14.91 mL 29.82 mL
5 mM 0.6 mL 2.98 mL 5.96 mL
10 mM 0.3 mL 1.49 mL 2.98 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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References for S4

References are publications that support the biological activity of the product.

Gieling et al (2012) Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J.Med.Chem. 55 5591 PMID: 22621623

If you know of a relevant reference for S4, please let us know.

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Keywords: S4, S4 supplier, carbonic, anhydrase, IX, XII, high, affinity, selective, inhibitors, inhibits, metastasis, migration, cancer, antimetastatic, Carbonic, anhydrases, 5577, Tocris Bioscience

Citations for S4

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Literature in this Area

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Cancer Metabolism Research Product Guide

Cancer Metabolism Research Product Guide

This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including: