S4

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Cat.No. 5577 - S4 | C15H17N3O4S | CAS No. 1330061-67-0
Description: High affinity and selective CA IX and CA XII inhibitor
Chemical Name: 4-[[[(3,5-Dimethylphenyl)amino]carbonyl]amino]phenyl sulfamate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

High affinity and selective CA IX and CA XII inhibitor (Ki values are 2, 7, 547 and 5600 nM for CA XII, IX, II and I, respectively). Inhibits migration and proliferation of breast cancer cells in vitro. Inhibits lung metastasis in mice bearing breast tumor xenografts, without affecting primary tumor.

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Technical Data

M. Wt 335.38
Formula C15H17N3O4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1330061-67-0
PubChem ID 53342705
InChI Key HGVHSNXRZYOTPD-UHFFFAOYSA-N
Smiles NS(OC1=CC=C(NC(NC2=CC(C)=CC(C)=C2)=O)C=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.54 100
ethanol 6.71 20

Preparing Stock Solutions

The following data is based on the product molecular weight 335.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.98 mL 14.91 mL 29.82 mL
5 mM 0.6 mL 2.98 mL 5.96 mL
10 mM 0.3 mL 1.49 mL 2.98 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Gieling et al (2012) Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J.Med.Chem. 55 5591 PMID: 22621623


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Keywords: S4, S4 supplier, carbonic, anhydrase, IX, XII, high, affinity, selective, inhibitors, inhibits, metastasis, migration, cancer, antimetastatic, Carbonic, anhydrases, 5577, Tocris Bioscience

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Literature in this Area

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis