STX 64

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Description: Potent steroid sulfatase inhibitor; also inhibits carbonic anhydrase II
Chemical Name: 6,7,8,9,10,11-Hexahydro-6-oxobenzo[b]cyclohepta[d]pyran-3-yl sulfamate
Purity: ≥98% (HPLC)

Biological Activity for STX 64

STX 64 is a potent steroid sulfatase inhibitor (IC50 = 8 nM). Estrone sulfate-stimulated uterine growth and mammary tumor growth are inhibited by STX 64 in animal models. STX 64 shows inhibition of steroid sulfatase activity in peripheral blood lymphocytes, liver and tumor tissues and is active in vivo. STX 64 is also a potent inhibitor of carbonic anhydrase II (IC50 = 25 nM).

Compound Libraries for STX 64

STX 64 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for STX 64

M. Wt 309.34
Formula C14H15NO5S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 288628-05-7
PubChem ID 5287541
Smiles O=C1OC=2C=C(OS(=O)(=O)N)C=CC2C3=C1CCCCC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for STX 64

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.93 100
ethanol 3.09 10

Preparing Stock Solutions for STX 64

The following data is based on the product molecular weight 309.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.23 mL 16.16 mL 32.33 mL
5 mM 0.65 mL 3.23 mL 6.47 mL
10 mM 0.32 mL 1.62 mL 3.23 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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References for STX 64

References are publications that support the biological activity of the product.

Ho et al (2003) Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates. Biochem.Biophys.Res.Commun. 305 909 PMID: 12767917

Purohit et al (2000) In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE. Cancer Res. 60 3394 PMID: 10910045

Raobaikady et al (2003) Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate. J.Steroid Biochem.Mol.Biol. 84 351 PMID: 12711022

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Keywords: STX 64, STX 64 supplier, STX64, potent, steroid, sulfatase, inhibitors, inhibits, esterases, tumor, carbonic, anhydrase, EC3.1.6.2, steryl-sulfatase, Other, Hydrolases, Carbonic, anhydrases, 7341, Tocris Bioscience

Citations for STX 64

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