p53 Signaling Pathway

Pathway Key Download PDF

p53 signaling plays an important role in the co-ordination of the cellular response to different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest. Inactivation of p53 has been implicated in tumor progression, it is thought that more than half of all cancers may involve p53-inactivating mutations.

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Signaling Pathway Key
Stimulates
Stimulates
Inhibits
Inhibits
Multistep Activation
Multistep Activation
Multistep Upregulation
Multistep Upregulation
Kinase
Kinase
Transcription Factor
Transcription Factor
Other Enzyme
Other Enzyme
Other Protein
Other Protein
Proapoptotic
Proapoptotic