Dynamin inhibitory peptide

Cat. No. 1774

Dynamin inhibitory peptide Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro

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Alternative Name: P4

Biological Activity

Peptide inhibitor of the GTPase dynamin; competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Reduces GABAA receptor internalization and increases miniature ISPC amplitude and frequency in neurons expressing GABAA receptors. Cell-permeable version also available (Cat. No. 1775).

Technical Data

Soluble to 1 mg/ml in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Nong et al (2003) Glycine binding primes NMDA receptor internalization. Nature 422 302. PMID: 12646920.

Kittler et al (2000) Constitutive endocytosis of GABAA receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J.Neurosci. 20 7972. PMID: 11050117.

Grabs et al (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. J.Biol.Chem. 272 13419. PMID: 9148966.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Dynamin inhibitory peptide include:

Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. J Neurosci 10 e0131430. PMID: 26102354.

Glebov et al (2015) Clathrin-independent trafficking of AMPA receptors. J Biol Chem 35 4830. PMID: 25810514.

Pleil et al (2015) NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking. Nat Neurosci 18 545. PMID: 25751534.

Chiang et al (2014) Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles. Nat Commun 5 3356. PMID: 24561832.

Cuitino et al (2010) Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons. PLoS One 30 8411. PMID: 20573888.

Graziane et al (2009) Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism. J Neurosci 284 8329. PMID: 19179335.

Dewerchin et al (2008) Surface-expressed viral proteins in feline infectious peritonitis virus-infected monocytes are internalized through a clathrin- and caveolae-independent pathway. J Gen Virol 89 2731. PMID: 18931069.

Xia et al (2007) Activity-dependent synaptic plasticity in retinal ganglion cells. J Neurosci 27 12221. PMID: 17989288.

Do you know of a great paper that uses Dynamin inhibitory peptide from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Dynamin inhibitory peptide, supplier, Dynamin, inhibitors, inhibits, Mitosis, Epac, GTPases, Tocris Bioscience, GTPase Inhibitor products

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