AICAR

Cat. No. 2840

AICAR C9H14N4O5 [2627-69-2]

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Chemical Name: N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide

Biological Activity

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro.

Technical Data

M.Wt:
258.23
Formula:
C9H14N4O5
Solubility:
Soluble to 75 mM in water and to 75 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
2627-69-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Wu et al (2011) AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells. Int.J.Artif.Organs. 34 1128. PMID: 22198598.

Giri et al (2008) The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: Implication for Krabbe disease. J.Neurochem. 105 1820. PMID: 18248608.

Kanazawa et al (2007) Adiponectin and AMP kinase activator stimulate proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells. BMC Cell Biol. 8 51. PMID: 18047638.

Giri et al (2004) 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. J.Neurosci. 24 479. PMID: 14724246.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for AICAR include:

Mo et al (2015) Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol 17 500. PMID: 25751140.

Jurmeister et al (2014) Transcriptomic analysis reveals inhibition of androgen receptor activity by AMPK in prostate cancer cells. Oncotarget 5 3785. PMID: 25003216.

Fong et al (2013) Moderate excess of pyruvate augments osteoclastogenesis. Biol Open 2 387. PMID: 23616923.

Creighton et al (2011) Adenosine monophosphate-activated kinase alpha1 promotes endothelial barrier repair. FASEB J 25 3356. PMID: 21680893.

Do you know of a great paper that uses AICAR from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: AICAR, supplier, AMPK, activators, AMP-Activated, Protein, Kinases, Enzyme, Substrates, Tocris Bioscience, AMPK Activator products

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