AICAR

Cat. No. 2840

AICAR C9H14N4O5 [2627-69-2]

Price and Availability

For AICAR pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide

Biological Activity

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro.

Technical Data

M.Wt:
258.23
Formula:
C9H14N4O5
Solubility:
Soluble to 75 mM in water and to 75 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
2627-69-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
Select another batch:

References are publications that support the products' biological activity.

Wu et al (2011) AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells. Int.J.Artif.Organs. 34 1128. PMID: 22198598.

Giri et al (2008) The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: Implication for Krabbe disease. J.Neurochem. 105 1820. PMID: 18248608.

Kanazawa et al (2007) Adiponectin and AMP kinase activator stimulate proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells. BMC Cell Biol. 8 51. PMID: 18047638.

Giri et al (2004) 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. J.Neurosci. 24 479. PMID: 14724246.

If you know of a relevant reference for AICAR please let us know.

Citations are publications that use Tocris products. Selected citations for AICAR include:

Mo et al (2015) Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol 17 500. PMID: 25751140.

Jurmeister et al (2014) Transcriptomic analysis reveals inhibition of androgen receptor activity by AMPK in prostate cancer cells. Oncotarget 5 3785. PMID: 25003216.

Mohseni et al (2014) A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway. PLoS One 16 108. PMID: 24362629.

Fong et al (2013) Moderate excess of pyruvate augments osteoclastogenesis. Biol Open 2 387. PMID: 23616923.

Hutchins et al (2013) Calcium release-dependent actin flow in the leading process mediates axophilic migration. J Pharmacol Exp Ther 33 11361. PMID: 23843509.

Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. FASEB J 8 e66404. PMID: 23799098.

Taub et al (2013) Distinct energy requirements for human memory CD4 T-cell homeostatic functions. BMC Cancer 27 342. PMID: 22972918.

Yung et al (2013) Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade. Stem Cells Transl Med 13 327. PMID: 23819460.

Terry et al (2012) Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Nat Cell Biol 109 3071. PMID: 22315427.

Bumpus and Johnson (2011) 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated protein kinase-independent. Proc Natl Acad Sci U S A 339 886. PMID: 21896918.

Creighton et al (2011) Adenosine monophosphate-activated kinase alpha1 promotes endothelial barrier repair. FASEB J 25 3356. PMID: 21680893.

Do you know of a great paper that uses AICAR from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Product Action

Keywords: AICAR, supplier, AMPK, activators, AMP-Activated, Protein, Kinases, Enzyme, Substrates, Tocris Bioscience, AMPK Activator products

Quick Order

Find multiple products by catalog number

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

AMPK Signaling Pathway

AMPK Signaling Pathway

AMPK signaling is involved in the downstream cellular response to low levels of ATP. View pathway or download PDF today.

divider line

New Products in this Area

P21d hydrochloride

Potent and selective Brk inhibitor

CVT 313

cdk2 inhibitor

TPPB

High affinity PKC activator; also APP modulator

JH 295

Irreversible Nek2 inhibitor

OXSI 2

Potent Syk kinase inhibitor; also inhibits assembly of NLRP3 inflammasomes

STK16-IN-1

Serine/threonine protein kinase 16 (STK16) inhibitor; also inhibits PI 3Kδ, PI 3Kγ and mTOR kinases.

AZ PFKFB3 26

Potent and selective PFKFB3 inhibitor

NCL 00017509

Potent and reversible NIMA related kinase 2 (Nek2) inhibitor

XMD 8-87

Potent Ack1/TNK2 inhibitor

SKI 178

Non-lipid sphingosine kinase 1 (SphK1) inhibitor

ML 315 hydrochloride

Inhibitor of Clk and DYRK kinases

Everolimus

mTOR inhibitor;immunosuppressant

PKI (5-24)

High affinity PKA inhibitor

TDZD 8

Selective non-ATP competitive inhibitor of GSK 3β

BI 605906

Selective IKKβ inhibitor

GSK 319347A

Potent and selective IKKε inhibitor

FRAX 597

Potent group I PAK inhibitor

MRT 68921 dihydrochloride

Potent ULK inhibitor; inhibits autophagy

AM 2394

Potent glucokinase activator; orally bioavailable

eCF 309

Potent mTOR inhibitor

PF 3758309 dihydrochloride

Potent PAK4 inhibitor; orally available

AZ Dyrk1B 33

Potent and selective Dyrk1B kinase inhibitor

PF 06409577

Potent and selective allosteric activator of AMPK

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.