Cat. No. 2840

AICAR C9H14N4O5 [2627-69-2]

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Chemical Name: N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide

Biological Activity

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro.

Technical Data

Soluble to 75 mM in water and to 75 mM in DMSO
>99 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Wu et al (2011) AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells. Int.J.Artif.Organs. 34 1128. PMID: 22198598.

Giri et al (2008) The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: Implication for Krabbe disease. J.Neurochem. 105 1820. PMID: 18248608.

Kanazawa et al (2007) Adiponectin and AMP kinase activator stimulate proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells. BMC Cell Biol. 8 51. PMID: 18047638.

Giri et al (2004) 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. J.Neurosci. 24 479. PMID: 14724246.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for AICAR include:

Mo et al (2015) Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol 17 500. PMID: 25751140.

Jurmeister et al (2014) Transcriptomic analysis reveals inhibition of androgen receptor activity by AMPK in prostate cancer cells. Oncotarget 5 3785. PMID: 25003216.

Mohseni et al (2014) A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway. PLoS One 16 108. PMID: 24362629.

Fong et al (2013) Moderate excess of pyruvate augments osteoclastogenesis. Biol Open 2 387. PMID: 23616923.

Hutchins et al (2013) Calcium release-dependent actin flow in the leading process mediates axophilic migration. J Pharmacol Exp Ther 33 11361. PMID: 23843509.

Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. FASEB J 8 e66404. PMID: 23799098.

Taub et al (2013) Distinct energy requirements for human memory CD4 T-cell homeostatic functions. BMC Cancer 27 342. PMID: 22972918.

Yung et al (2013) Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade. Stem Cells Transl Med 13 327. PMID: 23819460.

Terry et al (2012) Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection. Nat Cell Biol 109 3071. PMID: 22315427.

Bumpus and Johnson (2011) 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated protein kinase-independent. Proc Natl Acad Sci U S A 339 886. PMID: 21896918.

Creighton et al (2011) Adenosine monophosphate-activated kinase alpha1 promotes endothelial barrier repair. FASEB J 25 3356. PMID: 21680893.

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Keywords: AICAR, supplier, AMPK, activators, AMP-Activated, Protein, Kinases, Enzyme, Substrates, Tocris Bioscience, AMPK Activator products

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