AX 15836

Cat. No. 5843

AX 15836 C32H40N8O5S

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Chemical Name: 5,11-Dihydro-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-methyl,11-(methylsulfonyl)-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one

Biological Activity

Potent and selective ERK5 inhibitor (IC50 = 8 nM). Exhibits >1,000-fold selectivity for ERK5 over a panel of over 200 kinases. Also exhibits selectivity over bromodomain BRD4 (Kd = 3,600 nM).

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of AX15836 is reviewed on the chemical probes website.

Technical Data

M.Wt:
648.78
Formula:
C32H40N8O5S
Solubility:
Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Lin et al (2016) ERK5 kinase activity is dispensable for cellular immune response and proliferation. Proc.Natl.Acad.Sci.U.S.A. 113 11865. PMID: 27679845.

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Citations are publications that use Tocris products.

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View Related Products by Target

ERK

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Keywords: AX 15836, supplier, AX15836, potent, selective, ERK5, inhibitors, inhibits, Tocris Bioscience, ERK Inhibitor products

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