PF 06260933 dihydrochloride
Cat. No. 5752
Chemical Name: 5-(4-Chlorophenyl)-[3,3'-bipyridine]
Biological ActivityMAP4K4 (HGK) inhibitor (IC50 = 140 nM). Also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). Improves fasting hyperglycemia in mice. Orally active.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ammirati et al (2015) Discovery of an in vivo tool to establish proof-of-concept for MAP4K4-based antidiabetic treatment. ACS Med.Chem.Lett. 6 1128. PMID: 26617966.
If you know of a relevant reference for PF 06260933 dihydrochloride please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses PF 06260933 dihydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: PF 06260933 dihydrochloride, supplier, PF06260933, dihydrochloride, MAP4K4, HGK, inhibitors, inhibits, antidiabetic, diabetes, MINK, TNIK, mitogen-activated, kinases, hepatocyte, germinal, hepatocyte, pogenitor, kinase-like, germinal, center, kinase-like, kinase, Tocris Bioscience, Other MAPK Inhibitor products
Find multiple products by catalog number
New Products in this Area
High affinity JNK inhibitor; also inhibits HCMV replication
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.