(±)-ADX 71743

Cat. No. 5715new

()-ADX 71743 C17H19NO2

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Chemical Name: 6-(2,4-Dimethylphenyl)-2-ethyl-6,7-dihydro-4(5H)-benzoxazolone

Biological Activity

Negative allosteric modulator at mGlu7 (IC50 = 300 nM). Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices in vitro. Increases evoked excitatory postsynaptic currents (eEPSCs) in mice. Brain penetrant.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Tassin et al (2016) Phasic and tonic mGlu7 receptor activity modulates the thalamocortical network. Front Neural Circuits 10 31. PMID: 27199672.

Klar et al (2015) Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SC-CA1 synapses in the hippocampus. J.Neurosci. 35 7600. PMID: 25972184 .

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Keywords: ()-ADX 71743, supplier, ()-ADX, 71743, potent, negative, allosteric, modulators, NAMs, mGlu7, receptors, metabotropic, glutamate, epilepsy, 1431641-29-0, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Modulator products

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