Cat. No. 5715
Chemical Name: 6-(2,4-Dimethylphenyl)-2-ethyl-6,7-
Biological ActivityNegative allosteric modulator at mGlu7 (IC50 = 300 nM). Blocks high frequency-induced LTP at SC-CA1 synapses in hippocampal slices in vitro. Increases evoked excitatory postsynaptic currents (eEPSCs) in mice. Brain penetrant.
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Certificate of Analysis / Product Datasheet / Safety Data Sheet
Tassin et al (2016) Phasic and tonic mGlu7 receptor activity modulates the thalamocortical network. Front Neural Circuits 10 31. PMID: 27199672.
Klar et al (2015) Activation of metabotropic glutamate receptor 7 is required for induction of long-term potentiation at SC-CA1 synapses in the hippocampus. J.Neurosci. 35 7600. PMID: 25972184 .
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Keywords: (±)-ADX 71743, supplier, (±)-ADX, 71743, potent, negative, allosteric, modulators, NAMs, mGlu7, receptors, metabotropic, glutamate, epilepsy, 1431641-29-0, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Modulator products