Cat. No. 4225
Chemical Name: Octadecyltrimethylammonium bromide
Biological ActivityDynamin inhibitor (IC50 = 1.9 μM for dynamin I). Inhibits receptor-mediated endocytosis (IC50 = 16 μM). Displays similar activity to MitMAB (Cat. No. 4224).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Joshi et al (2010) The dynamin inhibitors MitMAB and OctMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. Mol.Cancer Ther. 9 1995. PMID: 20571068.
Quan et al (2007) Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II. Mol.Pharmacol. 72 1425. PMID: 17702890.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses OctMAB from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: OctMAB, supplier, dynamin, I, II, inhibitors, inhibits, gtpase, endocytosis, OctMAB, Tocris Bioscience, GTPase Inhibitor products