MitMAB

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Cat.No. 4224 - MitMAB | C17H38BrN | CAS No. 1119-97-7
Description: Dynamin inhibitor
Chemical Name: Tetradecyltrimethylammonium bromide
Datasheet
Citations
Literature

Biological Activity

Dynamin inhibitor; inhibits the GTPase activity of dynamin I (Ki = 940 nM; IC50 = 3.1 μM). Targets the dynamin-phospholipid interaction. Inhibits receptor-mediated endocytosis of epidermal growth factor (EGF) in non-neuronal cells; also inhibits synaptic vesicle endocytosis. Displays dynamin I-inhibitory activity similar to OctMAB (Cat. No. 4225).

Technical Data

M. Wt 336.39
Formula C17H38BrN
Storage Desiccate at RT
CAS Number 1119-97-7
PubChem ID 14250
InChI Key CXRFDZFCGOPDTD-UHFFFAOYSA-M
Smiles C[N+](C)(C)CCCCCCCCCCCCCC.[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 33.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 336.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.97 mL 14.86 mL 29.73 mL
5 mM 0.59 mL 2.97 mL 5.95 mL
10 mM 0.3 mL 1.49 mL 2.97 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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References

References are publications that support the products' biological activity.

Hill et al (2004) Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity. Bioorg.Med.Chem.Lett. 14 3275 PMID: 15149689

Quan et al (2007) Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II. Mol.Pharmacol. 72 1425 PMID: 17702890

de Beco et al (2009) Endocytosis is required for E-cadherin redistribution at mature adherens junctions. Proc.Natl.Acad.Sci. 106 7010 PMID:


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Keywords: dynamin I II inhibitors inhibits gtpase endocytosis MitMAB GTPase

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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  • Signal Transduction
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