MitMAB

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Cat.No. 4224 - MitMAB | C17H38BrN | CAS No. 1119-97-7
Description: Dynamin inhibitor
Chemical Name: Tetradecyltrimethylammonium bromide
Datasheet
Citations
Reviews (1)
Literature (1)

Biological Activity

Dynamin inhibitor; inhibits the GTPase activity of dynamin I (Ki = 940 nM; IC50 = 3.1 μM). Targets the dynamin-phospholipid interaction. Inhibits receptor-mediated endocytosis of epidermal growth factor (EGF) in non-neuronal cells; also inhibits synaptic vesicle endocytosis. Displays dynamin I-inhibitory activity similar to OctMAB (Cat. No. 4225).

Technical Data

M. Wt 336.39
Formula C17H38BrN
Storage Desiccate at RT
CAS Number 1119-97-7
PubChem ID 14250
InChI Key CXRFDZFCGOPDTD-UHFFFAOYSA-M
Smiles C[N+](C)(C)CCCCCCCCCCCCCC.[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 33.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 336.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.97 mL 14.86 mL 29.73 mL
5 mM 0.59 mL 2.97 mL 5.95 mL
10 mM 0.3 mL 1.49 mL 2.97 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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References

References are publications that support the biological activity of the product.

Hill et al (2004) Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity. Bioorg.Med.Chem.Lett. 14 3275 PMID: 15149689

Quan et al (2007) Myristyl trimethyl ammonium bromide and octadecyl trimethyl ammonium bromide are surface-active small molecule dynamin inhibitors that block endocytosis mediated by dynamin I or dynamin II. Mol.Pharmacol. 72 1425 PMID: 17702890

de Beco et al (2009) Endocytosis is required for E-cadherin redistribution at mature adherens junctions. Proc.Natl.Acad.Sci. 106 7010


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Keywords: MitMAB, MitMAB supplier, dynamin, I, II, inhibitors, inhibits, gtpase, endocytosis, MitMAB, Mitosis, Dynamin, 4224, Tocris Bioscience

Citations for MitMAB

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Apoptosis was induced by MitMAB in PC3 cells.
By Anonymous on 02/11/2019
Species: Human

Apoptosis was induced by MitMAB in PC3 cells. The figure shows the results from DAPI staining obtained via EVOSTM Floid Florescence Microscope X80 magnification.

review image

Literature in this Area

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