Rhosin hydrochloride

Cat. No. 5003

Rhosin hydrochloride C20H18N6O.HCl [1281870-42-5]

Price and Availability

For Rhosin hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride

Biological Activity

Rho GTPase inhibitor (Kd = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro. Also induces neurite outgrowth in synergy with NGF.

Technical Data

M.Wt:
394.86
Formula:
C20H18N6O.HCl
Solubility:
Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1281870-42-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Shang et al (2013) Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proc.Natl.Acad.Sci.U.S.A. 110 3155. PMID: 23382194.

Shang et al (2012) Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chem.Biol. 19 699. PMID: 22726684.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Rhosin hydrochloride from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: Rhosin hydrochloride, supplier, Rho, GTPases, inhibitors, inhibits, guanine, nucleotide, exchange, factors, GEF, Tocris Bioscience, GTPase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Fall/Winter 2016)

Our New Product guide highlights over 100 new products added in the second half of 2016. Request copy or view PDF today.

divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.