ZCL 278

Cat. No. 4794

ZCL 278 C21H19BrClN5O4S2 [587841-73-4]

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Chemical Name: 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]thioxomethyl]acetamide

Biological Activity

Selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.

Technical Data

Soluble to 100 mM in DMSO
>95 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Friesland et al (2013) Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc.Natl.Acad.Sci.USA 110 1261. PMID: 23284167.

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Citations are publications that use Tocris products. Selected citations for ZCL 278 include:

Bijata et al (2015) Dystroglycan controls dendritic morphogenesis of hippocampal neurons in vitro. Front Cell Neurosci 9 199. PMID: 26074769.

Speranza et al (2015) Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. Nat Biotechnol 9 62. PMID: 25814944.

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Keywords: ZCL 278, supplier, ZCL278, Cdc42, Rho, small, GTPases, inhibitors, inhibits, Tocris Bioscience, GTPase Inhibitor products

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