Cat. No. 4794
Chemical Name: 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-
Biological ActivitySelective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Friesland et al (2013) Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc.Natl.Acad.Sci.USA 110 1261. PMID: 23284167.
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Citations are publications that use Tocris products. Selected citations for ZCL 278 include:
Bijata et al (2015) Dystroglycan controls dendritic morphogenesis of hippocampal neurons in vitro. Front Cell Neurosci 9 199. PMID: 26074769.
Speranza et al (2015) Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. Nat Biotechnol 9 62. PMID: 25814944.
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Keywords: ZCL 278, supplier, ZCL278, Cdc42, Rho, small, GTPases, inhibitors, inhibits, Tocris Bioscience, GTPase Inhibitor products
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