Cat. No. 4793
Chemical Name: 5,7-Dibromo-6-fluoro-3,4-dihydro-2-
Biological ActivityUncompetitive Epac1 inhibitor. Blocks Epac-induced Rap activation and prevents isoprenaline-induced autophagy flux in cardiomyocytes. Has no effect on PKA activity in the presence of cAMP.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Laurent et al (2015) Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy. Cardiovasc.Res. 105 55. PMID: 25411381.
Courilleau et al (2012) Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac. J.Biol.Chem. 287 44192. PMID: 23139415.
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Keywords: CE3F4, supplier, uncompetitive, Epac1, inhibitors, inhibits, autophagy, Exchange, proteins, Tocris Bioscience, GTPase Inhibitor products
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