Cat. No. 4793
Chemical Name: 5,7-Dibromo-6-fluoro-3,4-dihydro-2-
Biological ActivityUncompetitive Epac1 inhibitor. Blocks Epac-induced Rap activation and prevents isoprenaline-induced autophagy flux in cardiomyocytes. Has no effect on PKA activity in the presence of cAMP.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Laurent et al (2015) Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy. Cardiovasc.Res. 105 55. PMID: 25411381.
Courilleau et al (2012) Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac. J.Biol.Chem. 287 44192. PMID: 23139415.
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Keywords: CE3F4, supplier, uncompetitive, Epac1, inhibitors, inhibits, autophagy, Exchange, proteins, Tocris Bioscience, GTPase Inhibitor products