CE3F4

Cat. No. 4793

CE3F4 C11H10Br2FNO [143703-25-7]

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Chemical Name: 5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde

Biological Activity

Uncompetitive Epac1 inhibitor. Blocks Epac-induced Rap activation and prevents isoprenaline-induced autophagy flux in cardiomyocytes. Has no effect on PKA activity in the presence of cAMP.

Technical Data

M.Wt:
351.01
Formula:
C11H10Br2FNO
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
143703-25-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Laurent et al (2015) Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy. Cardiovasc.Res. 105 55. PMID: 25411381.

Courilleau et al (2012) Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac. J.Biol.Chem. 287 44192. PMID: 23139415.

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Citations are publications that use Tocris products.

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View Related Products by Product Action

Keywords: CE3F4, supplier, uncompetitive, Epac1, inhibitors, inhibits, autophagy, Exchange, proteins, Tocris Bioscience, GTPase Inhibitor products

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