16,16-Dimethyl Prostaglandin E2

Cat. No. 4027

16,16-Dimethyl Prostaglandin E2 C22H36O5 [39746-25-3]

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Chemical Name: (5Z,11α,13E,15R)-11,15-Dihydroxy-16,16-dimethyl-9-oxo-prosta-5,13-dien-1oic acid

Biological Activity

Synthetic derivative of prostaglandin E2 (Cat. No. 2296). Increases embryonic stem cell (ESC) hematopoietic colony formation in mouse bone marrow. Also induces an increase in hematopoietic stem cell (HSC) numbers and enhances Wnt activity within the HSC population in zebrafish embryos.

Technical Data

Soluble in methyl acetate (supplied pre-dissolved -10mg/ml)
>98 %
Store at -80°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Goessling et al (2009) Genetic interaction of PGE2 and wnt signaling regulates developmental specification of stem cells and regeneration. Cell 136 1136. PMID: 19303855.

Lord et al (2007) Prostaglandin E2: making more of your marrow. Cell Cycle 6 3054. PMID: 18075310.

North et al (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. 447 1007. PMID: 17581586.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 16,16-Dimethyl Prostaglandin E2 include:

Jansen et al (2015) Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization. Oncotarget 19 210. PMID: 25266063.

Do you know of a great paper that uses 16,16-Dimethyl Prostaglandin E2 from Tocris? If so please let us know.

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Keywords: 16,16-Dimethyl Prostaglandin E2, supplier, synthetic, prostaglandin, prostanoid, receptors, agonists, hematopoietic, haematopoietic, stem, cells, HSCs, PGE2, organoids, Tocris Bioscience, Prostanoid Receptor Agonist products

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