16,16-Dimethyl Prostaglandin E2
Cat. No. 4027
Chemical Name: (5Z,11α,13E,15R)-11,15-Dihydroxy-16,
Biological ActivitySynthetic derivative of prostaglandin E2 (Cat. No. 2296). Increases embryonic stem cell (ESC) hematopoietic colony formation in mouse bone marrow. Also induces an increase in hematopoietic stem cell (HSC) numbers and enhances Wnt activity within the HSC population in zebrafish embryos.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Goessling et al (2009) Genetic interaction of PGE2 and wnt signaling regulates developmental specification of stem cells and regeneration. Cell 136 1136. PMID: 19303855.
Lord et al (2007) Prostaglandin E2: making more of your marrow. Cell Cycle 6 3054. PMID: 18075310.
North et al (2007) Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. 447 1007. PMID: 17581586.
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Citations are publications that use Tocris products. Selected citations for 16,16-Dimethyl Prostaglandin E2 include:
Jansen et al (2015) Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization. Oncotarget 19 210. PMID: 25266063.
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Keywords: 16,16-Dimethyl Prostaglandin E2, supplier, synthetic, prostaglandin, prostanoid, receptors, agonists, hematopoietic, haematopoietic, stem, cells, HSCs, PGE2, organoids, Tocris Bioscience, Prostanoid Receptor Agonist products
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