ITX 3

Cat. No. 3792

ITX 3 C22H17N3OS [347323-96-0]

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Chemical Name: (E)-2-[(2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]thiazolo[3,2-a]benzimidazol-3(2H)-one

Biological Activity

Selective inhibitor of TrioN RhoGEF activity. Inhibits TrioN-mediated GTP exchange on RhoG and Rac1, formation of TrioN-induced cellular structures in REF52 fibroblasts and NGF-mediated neurite outgrowth in PC12 cells in vitro.

Technical Data

M.Wt:
371.45
Formula:
C22H17N3OS
Solubility:
Soluble to 5 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
347323-96-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Bouquier et al (2009) A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem.Biol. 16 657. PMID: 19549603.

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Keywords: ITX 3, supplier, ITX3, selective, TrioN, RhoGEFs, guanine, nucleotide, exchange, factors, inhibitors, inhibits, RhoG, Rac1, GTPases, small, G, proteins, Tocris Bioscience, GTPase Inhibitor products

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