Cat. No. 3792
Chemical Name: (E)-2-[(2,5-Dimethyl-1-phenyl-1H-py
Biological ActivitySelective inhibitor of TrioN RhoGEF activity. Inhibits TrioN-mediated GTP exchange on RhoG and Rac1, formation of TrioN-induced cellular structures in REF52 fibroblasts and NGF-mediated neurite outgrowth in PC12 cells in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Bouquier et al (2009) A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem.Biol. 16 657. PMID: 19549603.
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Keywords: ITX 3, supplier, ITX3, selective, TrioN, RhoGEFs, guanine, nucleotide, exchange, factors, inhibitors, inhibits, RhoG, Rac1, GTPases, small, G, proteins, Tocris Bioscience, GTPase Inhibitor products