XAV 939

Cat. No. 3748

XAV 939 C14H11F3N2OS [284028-89-3]

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Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one

Biological Activity

Potent tankyrase (TNKS) inhibitor (IC50 values are 4 and 11 nM for TNKS2 and TNKS1 respectively). Antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the β-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm progenitor cells.

Technical Data

Soluble to 20 mM in DMSO
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Wang et al (2010) Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling. ACS Chem. Biol. 6 192. PMID: 21077691.

Adler (2009) Inhibiting wnt signaling. Sci.Signal. 91.

Huang et al (2009) Tankyrase inhibition stabilizes axin and antagonizes wnt signalling. Nature 461 614. PMID: 19759537.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for XAV 939 include:

Gerbin et al (2015) Enhanced Electrical Integration of Engineered Human Myocardium via Intramyocardial versus Epicardial Delivery in Infarcted Rat Hearts. PLoS One 10 e0131446. PMID: 26161513.

Jain et al (2015) Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. Nat Commun 6 6727. PMID: 25865356.

Jansen et al (2015) Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization. Blood 19 210. PMID: 25266063.

Ma et al (2015) Downregulation of Wnt signaling by sonic hedgehog activation promotes repopulation of human tumor cell lines. J Cell Mol Med 8 385. PMID: 25713298.

Palpant et al (2015) Cardiac development in zebrafish and human embryonic stem cells is inhibited by exposure to tobacco cigarettes and e-cigarettes. PLoS One 10 e0126259. PMID: 25978043.

Szabo et al (2015) Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development. Dis Model Mech 16 126. PMID: 26076956.

Wiedermann et al (2015) A balance of positive and negative regulators determines the pace of the segmentation clock. Elife 4. PMID: 26357015.

Jiang et al (2013) WNT3 is a biomarker capable of predicting the definitive endoderm differentiation potential of hESCs. Stem Cell Reports 1 46. PMID: 24052941.

Jiang et al (2013) Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway. ASN Neuro 23 122. PMID: 22907667.

Myers and Krieg (2013) BMP-mediated specification of the erythroid lineage suppresses endothelial development in blood island precursors. Blood 122 3929. PMID: 24100450.

Palpant et al (2013) Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development. Development 140 3799. PMID: 23924634.

Wang et al (2013) Critical roles of p53 in epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma cells. Genome Biol 8 e72846. PMID: 24023784.

Wu et al (2012) Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation. J Neurosci 32 6651. PMID: 22573687.

Barber and Sentman (2011) NKG2D receptor regulates human effector T-cell cytokine production. Cell Res 117 6571. PMID: 21518928.

Fancy et al (2011) Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. Nat Neurosci 14 1009. PMID: 21706018.

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Keywords: XAV 939, supplier, XAV939, wnt, signalling, signaling, b-catenin, β-catenin, beta-catenin, axin, TNKS1, TNKS2, tankyrase, inhibitors, inhibits, PARP, poly(ADP-ribose), polymerases, cardiogenesis, Tocris Bioscience, Tankyrase Inhibitor products

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