Golgicide A

Cat. No. 3584

Golgicide A C17H14F2N2 [1139889-93-2]

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Chemical Name: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

Biological Activity

Potent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Arrests secretion of soluble and membrane-associated proteins at the endoplasmic reticulum-Golgi intermediate compartment. Causes disassembly and dispersal of the Golgi and trans-Golgi network.

Technical Data

M.Wt:
284.3
Formula:
C17H14F2N2
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
1139889-93-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Saenz et al (2008) Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nature Chem.Biol. 5 157.

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Keywords: Golgicide A, supplier, potent, specific, reversible, inhibitors, inhibits, Golgi, BFA, resistance, factors, 1, GBF1, ArfGEF, ADP, ribosylation, factor, guanine, nucleotide, exchange, Tocris Bioscience, GTPase Inhibitor products

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