Cat. No. 3584
Chemical Name: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,
Biological ActivityPotent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Arrests secretion of soluble and membrane-associated proteins at the endoplasmic reticulum-Golgi intermediate compartment. Causes disassembly and dispersal of the Golgi and trans-Golgi network.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Saenz et al (2008) Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nature Chem.Biol. 5 157.
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Keywords: Golgicide A, supplier, potent, specific, reversible, inhibitors, inhibits, Golgi, BFA, resistance, factors, 1, GBF1, ArfGEF, ADP, ribosylation, factor, guanine, nucleotide, exchange, Tocris Bioscience, GTPase Inhibitor products