Prochlorperazine dimaleate

Cat. No. 3287

Prochlorperazine dimaleate C20H24ClN3S.2C4H4O4 [84-02-6]

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Chemical Name: 2-Chloro-10-[3[(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine dimaleate

Biological Activity

D2 receptor antagonist. Also interacts with 5-HT3 and nAChR. Displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo.

Technical Data

M.Wt:
606.09
Formula:
C20H24ClN3S.2C4H4O4
Solubility:
Soluble to 25 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
84-02-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Satoh et al (2005) The antipsychotic and antiemetic drug prochlorperazine delays the ventricular repolarization of the in situ canine heart. J.Pharm.Sci. 97 101.

Ghelardini et al (2004) Prochlorperazine induces central antinociception mediated by the muscarinic system. Pharmacol.Res. 50 351. PMID: 15225680.

Lummis and Baker (1997) Radioligand binding and photoaffinity labeling studies show a direct interaction of phenothiazenes at 5-HT3 receptors. Neuropharmacology 36 665. PMID: 9225292.

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Keywords: Prochlorperazine dimaleate, supplier, D2, receptor, antagonists, 5-HT3, nAChR, Dopamine, Receptors, serotonin, dopaminergic, Tocris Bioscience, D2 Receptor Antagonist products

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