Endothelin 1 (human, porcine)
Cat. No. 1160
Alternative Name: ET-1
Biological ActivityEndogenous potent vasoconstrictor peptide that is an agonist at ETA and ETB receptors. Modulates vascular tone.
(Modifications: Disulfide bridge between 1 - 15, 3 - 11)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Servitja et al (1998) Involvement of ETA and ETB receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes. Br.J.Pharmacol. 124 1728. PMID: 9756390.
Inoue et al (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc.Natl.Acad.Sci.U.S.A. 86 2863. PMID: 2649896.
Yanagisawa and Masaski (1989) Molecular biology and biochemistry of the endothelins. TiPS 10 374. PMID: 2690429.
Yanagisawa et al (1988) Primary structure, synthesis, and biological activity of rat endothelin, and endothelium-derived vasoconstrictor peptide. Proc.Natl.Acad.Sci.U.S.A. 85 6964. PMID: 3045827.
If you know of a relevant reference for Endothelin 1 (human, porcine) please let us know.
Citations are publications that use Tocris products. Selected citations for Endothelin 1 (human, porcine) include:
Yuan et al (2015) Endothelial cells enhance the migration of bovine meniscus cells. J Neurosci 67 182. PMID: 25307081.
Needham et al (2014) The role of K+ and Cl- channels in the regulation of retinal arteriolar tone and blood flow. J Pharmacol Exp Ther 55 2157. PMID: 24609622.
Hamby et al (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. Invest Ophthalmol Vis Sci 32 14489. PMID: 23077035.
McQueen et al (2007) Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice. Br J Pharmacol 151 278. PMID: 17351652.
Khan et al (2006) Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. Br J Pharmacol 147 607. PMID: 16432510.
Cirino et al (2003) Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function. Arthritis Rheumatol 100 5531. PMID: 12707413.
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Keywords: Endothelin 1 (human, porcine), supplier, Potent, vasoconstrictor, peptide, Endothelin, Non-Selective, ET, Receptors, agonists, Endothelin1, (human, porcine), Tocris Bioscience, Non-selective Endothelin Agonist products
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High affinity dual ETA and ETB receptor antagonist;orally bioavailable
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