Endothelin 1 (human, porcine)
Cat. No. 1160
Alternative Name: ET-1
Biological ActivityEndogenous potent vasoconstrictor peptide that is an agonist at ETA and ETB receptors. Modulates vascular tone.
(Modifications: Disulfide bridge between 1 - 15, 3 - 11)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Servitja et al (1998) Involvement of ETA and ETB receptors in the activation of phospholipase D by endothelins in cultured rat cortical astrocytes. Br.J.Pharmacol. 124 1728. PMID: 9756390.
Inoue et al (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc.Natl.Acad.Sci.U.S.A. 86 2863. PMID: 2649896.
Yanagisawa and Masaski (1989) Molecular biology and biochemistry of the endothelins. TiPS 10 374. PMID: 2690429.
Yanagisawa et al (1988) Primary structure, synthesis, and biological activity of rat endothelin, and endothelium-derived vasoconstrictor peptide. Proc.Natl.Acad.Sci.U.S.A. 85 6964. PMID: 3045827.
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Citations are publications that use Tocris products. Selected citations for Endothelin 1 (human, porcine) include:
McQueen et al (2007) Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice. Br J Pharmacol 151 278. PMID: 17351652.
Khan et al (2006) Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. Br J Pharmacol 147 607. PMID: 16432510.
Do you know of a great paper that uses Endothelin 1 (human, porcine) from Tocris? If so please let us know.
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Keywords: Endothelin 1 (human, porcine), supplier, Potent, vasoconstrictor, peptide, Endothelin, Non-Selective, ET, Receptors, agonists, Endothelin1, (human, porcine), Tocris Bioscience, Non-selective Endothelin Agonist products