Cat. No. 0344
Chemical Name: γ-Aminobutyric acid
Biological ActivityEndogenous inhibitory neurotransmitter. Caged RuBi GABA is also available (Cat. No. 3400).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Johnston (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319. PMID: 8885697.
Malcangio and Bowery (1996) GABA and its receptors in the spinal cord. TiPS 17 457. PMID: 9014500.
Decavel and van den Pol (1990) GABA: a dominant transmitter in the hypothalamus. J.Comp.Neurol. 302 1019. PMID: 2081813.
Curtis et al (1970) GABA, bicuculline and central inhibition. Nature 226 1222. PMID: 4393081.
If you know of a relevant reference for GABA please let us know.
Citations are publications that use Tocris products. Selected citations for GABA include:
David-Pereira (2017) The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex. Neuroscience 349 341. PMID: 28300633.
Lecat-Guillet et al (2017) FRET-based sensors unravel activation and allosteric modulation of the GABAB receptor. Cell Chem Biol 24 (3) 360. PMID: 28286129.
Selten et al (2016) Increased GABAB receptor signaling in a rat model for schizophrenia Scientific Reports 6 34240. PMID: 27687783.
Chanda et al (2014) Generation of induced neuronal cells by the single reprogramming factor ASCL1. Eur J Neurosci 3 282. PMID: 25254342.
Xia et al (2014) Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS One 9 e100968. PMID: 24971996.
Fuchs et al (2013) GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses. Evid Based Complement Alternat Med 38 3146. PMID: 23909897.
Ring et al (2012) GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium. PLoS One 7 e36874. PMID: 22590629.
Sciolino et al (2012) Voluntary exercise offers anxiolytic potential and amplifies galanin gene expression in the locus coeruleus of the rat. Behav Brain Res 233 191. PMID: 22580167.
Atherton et al (2008) Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus. J Physiol 586 5679. PMID: 18832425.
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Keywords: GABA, supplier, Endogenous, agonists, GABAA, Receptors, GABAC, GABAB, IAA, inhibitory, amino, acid, gamma-Aminobutyric, γ-aminobutyric, g-Aminobutyric, Tocris Bioscience, GABAA Receptor Agonist products
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