RuBi-GABA

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Cat.No. 3400 - RuBi-GABA | C42H39F6N5O2P2Ru | CAS No. 1028141-88-9
Description: Caged GABA; excitable by visible wavelength
Chemical Name: (bis(2,2'-Bipyridine-N,N')triphenylphosphine)-4-aminobutyric acid ruthenium hexafluorophosphate complex
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Ruthenium-bipyridine-triphenylphosphine caged GABA (Cat. No. 0344) that is excited by visible wavelengths. Provides greater tissue penetration, less phototoxicity, faster photorelease kinetics and better spatial resolution than UV light-sensitive caged compounds. Produces GABA receptor-mediated currents in pyramidal neurons in vitro and displays no effect on endogenous GABAergic or glutamatergic transmission at concentrations effective for uncaging.

Licensing Information

Sold under licence from Columbia University

Technical Data

M. Wt 922.8
Formula C42H39F6N5O2P2Ru
Storage Store at -20°C
CAS Number 1028141-88-9
PubChem ID 117071637
InChI Key YMUDUHPMAODLNP-UHFFFAOYSA-N
Smiles [Ru++].NCCCC([O-])=O.F[P-](F)(F)(F)(F)F.C1=CN=C(C=C1)C1=CC=CC=N1.C1=CC=C(N=C1)C1=CC=CC=N1.C1=CC=C(C=C1)P(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility

Please refer to these solubility guidelines for RuBi-GABA (Cat. No. 3400).

Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Zayat et al (2003) A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage. J.Am.Chem.Soc. 125 882 PMID: 12537482

Rial Verde et al (2008) Photorelease of GABA with visible light using an inorganic caging group. Front.Neural Circuits 2 2 PMID: 18946542


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Keywords: RuBi-GABA, RuBi-GABA supplier, Caged, GABA, GABAA, GABAC, Receptors, GABAB, Compounds, Miscellaneous, 3400, Tocris Bioscience

1 Citation for RuBi-GABA

Citations are publications that use Tocris products. Selected citations for RuBi-GABA include:

Amatrudo et al (2015) Caged compounds for multichromic optical interrogation of neural systems. Int J Oncol 41 42491 PMID: 25471355


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