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Description: Caged GABA; excitable at visible wavelengths
Chemical Name: (bis(2,2'-Bipyridine-N,N')triphenylphosphine)-4-aminobutyric acid ruthenium hexafluorophosphate complex
Citations (1)
Literature (2)

Biological Activity for RuBi-GABA

RuBi-GABA is a ruthenium-bipyridine-triphenylphosphine caged GABA (Cat. No. 0344) that is excited by visible wavelengths. Provides greater tissue penetration, less phototoxicity, faster photorelease kinetics and better spatial resolution than UV light-sensitive caged compounds. Produces GABA receptor-mediated currents in pyramidal neurons in vitro and displays no effect on endogenous GABAergic or glutamatergic transmission at concentrations effective for uncaging.

Licensing Information

Sold under licence from Columbia University

Technical Data for RuBi-GABA

M. Wt 922.8
Formula C42H39F6N5O2P2Ru
Storage Store at -20°C
CAS Number 1028141-88-9
PubChem ID 117071637
Smiles [Ru++].NCCCC([O-])=O.F[P-](F)(F)(F)(F)F.C1=CN=C(C=C1)C1=CC=CC=N1.C1=CC=C(N=C1)C1=CC=CC=N1.C1=CC=C(C=C1)P(C1=CC=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RuBi-GABA

Please refer to these solubility guidelines for RuBi-GABA (Cat. No. 3400).

Product Datasheets for RuBi-GABA

Certificate of Analysis / Product Datasheet
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References for RuBi-GABA

References are publications that support the biological activity of the product.

Zayat et al (2003) A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage. J.Am.Chem.Soc. 125 882 PMID: 12537482

Rial Verde et al (2008) Photorelease of GABA with visible light using an inorganic caging group. Front.Neural Circuits 2 2 PMID: 18946542

If you know of a relevant reference for RuBi-GABA, please let us know.

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Keywords: RuBi-GABA, RuBi-GABA supplier, Caged, GABA, GABAA, GABAC, Receptors, GABAB, Compounds, Miscellaneous, 3400, Tocris Bioscience

1 Citation for RuBi-GABA

Citations are publications that use Tocris products. Selected citations for RuBi-GABA include:

Amatrudo et al (2015) Caged compounds for multichromic optical interrogation of neural systems. Int J Oncol 41 42491 PMID: 25471355

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

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Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.