Zotepine

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Cat.No. 3996 - Zotepine | C18H18ClNOS | CAS No. 26615-21-4
Description: 5-HT2A/D2 antagonist; atypical antipsychotic
Chemical Name: 2-[(8-Chlorodibenzo(Z)[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

5-HT2A receptor and dopamine D2 receptor antagonist (Ki values are 0.69 and 2.3 nM respectively). Also a potent histamine H1 receptor antagonist (IC50 = 8.0 nM). Atypical antipsychotic; exhibits antidepressive and anxiolytic effects in vivo.

Technical Data

M. Wt 331.86
Formula C18H18ClNOS
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 26615-21-4
PubChem ID 5736
InChI Key HDOZVRUNCMBHFH-UHFFFAOYSA-N
Smiles ClC3=CC=C2SC1=CC=CC=C1C=C(OCCN(C)C)C2=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.59 50
ethanol 16.59 50

Preparing Stock Solutions

The following data is based on the product molecular weight 331.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.07 mL 30.13 mL
5 mM 0.6 mL 3.01 mL 6.03 mL
10 mM 0.3 mL 1.51 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Herrick-Davis et al (2000) Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors. J.Pharmacol.Exp.Ther. 295 226 PMID: 10991983

Yamamura et al (2009) Effects of zotepine on extracellular levels of monamine, GABA and glutamate in rat prefrontal cortex. Br.J.Pharmacol. 157 656 PMID: 19371334

Shobo et al (2010) Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptake. J.Pharmacol.Exp.Ther. 333 772 PMID: 20223878


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Citations for Zotepine

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