Zopiclone

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Cat.No. 1094 - Zopiclone | C17H17ClN6O3 | CAS No. 43200-80-2
Description: Benzodiazepine agonist
Chemical Name: 4-Methyl-1-piperazinecarboxylic acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b] pyrazin-5-yl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

A non benzodiazepine BZR agonist, with little difference in affinity for the BZ1 and BZ2 subtypes; however its CNS effects differ from those of other BZR ligands and this may be due to interaction with a different subunit.

Technical Data

M. Wt 388.81
Formula C17H17ClN6O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 43200-80-2
PubChem ID 5735
InChI Key GBBSUAFBMRNDJC-UHFFFAOYSA-N
Smiles CN1CCN(CC1)C(=O)OC1N(C(=O)C2=NC=CN=C12)C1=CC=C(Cl)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.16 75

Preparing Stock Solutions

The following data is based on the product molecular weight 388.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.57 mL 12.86 mL 25.72 mL
5 mM 0.51 mL 2.57 mL 5.14 mL
10 mM 0.26 mL 1.29 mL 2.57 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Goa and Heel (1986) Zopiclone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy as a hypnotic. Drugs 32 48 PMID: 2874974

Im et al (1993) Potentiation of γ-aminobutyric acid induced chloride currents by various benzodiazepine site agonists with the α1γ2, β2γ2 and α1β2γ2 subtypes of cloned γ-aminobutyric acid type A receptors. Mol.Pharmacol. 44 866 PMID: 7901754

Munakata et al (1996) Heterogeneous distribution of benzodiazepine receptors among rat neostriatal neurones. Br.J.Pharmacol. 118 820 PMID: 8762113


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Keywords: Zopiclone, supplier, Benzodiazepine, agonists, GABAA, Receptors, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience

Citations for Zopiclone

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