Discontinued Product

Zolpidem (Cat. No. 0655) has been withdrawn from sale for commercial reasons.
Description: Benzodiazepine agonist
Chemical Name: N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide
Purity: ≥99% (HPLC)
Citations (7)
Literature (2)

Biological Activity for Zolpidem

Benzodiazepine agonist with high selectivity for α1-subunit-containing GABAA receptors (BZ/ω1 site) and very high intrinsic activity. Ki values are 20, 400 and ≥ 5000 nM for α1-, α2-/α3-, and α5-containing GABAA receptors respectively. Hypnotic that does not induce physical dependence.

Technical Data for Zolpidem

M. Wt 307.39
Formula C19H21N3O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 82626-48-0
PubChem ID 5732
Smiles O=C(N(C)C)CC1=C(C3=CC=C(C)C=C3)N=C2N1C=C(C)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Zolpidem

Certificate of Analysis / Product Datasheet
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References for Zolpidem

References are publications that support the biological activity of the product.

Arbilla et al (1986) High affinity [3H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors. Eur.J.Pharmacol. 130 257 PMID: 2878820

Crestani et al (2000) Mechanism of action of the hypnotic zol. in vivo. Br.J.Pharmacol. 131 1251 PMID: 11090095

Depoortere et al (1986) Zolpidem, a novel nonbenzodiazepine hypnotic. 1. Neuropharmacological and behavioural effects. J.Pharmacol.Exp.Ther. 237 649 PMID: 2871178

Perrault et al (1992) Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zol. J.Pharmacol.Exp.Ther. 263 298 PMID: 1403792

Soderhielm et al (2018) Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors. Biochem.Pharmacol. 158 339 PMID: 30121248

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Keywords: Zolpidem, Zolpidem supplier, Benzodiazepine, agonists, GABAA, Receptors, 0655, Tocris Bioscience

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GABA Receptors Scientific Review

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.