Zolpidem

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Cat.No. 0655 - Zolpidem | C19H21N3O | CAS No. 82626-48-0
Description: Benzodiazepine agonist
Chemical Name: N,N,6-Trimethyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide
Purity: ≥99% (HPLC)
Datasheet
Citations (7)
Reviews
Literature

Biological Activity

Benzodiazepine agonist with high selectivity for α1-subunit-containing GABAA receptors (BZ/ω1 site) and very high intrinsic activity. Ki values are 20, 400 and ≥ 5000 nM for α1-, α2-/α3-, and α5-containing GABAA receptors respectively. Hypnotic that does not induce physical dependence.

Technical Data

M. Wt 307.39
Formula C19H21N3O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 82626-48-0
PubChem ID 5732
InChI Key ZAFYATHCZYHLPB-UHFFFAOYSA-N
Smiles O=C(N(C)C)CC1=C(C3=CC=C(C)C=C3)N=C2N1C=C(C)C=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 30.74 100
DMSO 15.37 50

Preparing Stock Solutions

The following data is based on the product molecular weight 307.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.25 mL 16.27 mL 32.53 mL
5 mM 0.65 mL 3.25 mL 6.51 mL
10 mM 0.33 mL 1.63 mL 3.25 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Arbilla et al (1986) High affinity [3H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors. Eur.J.Pharmacol. 130 257 PMID: 2878820

Crestani et al (2000) Mechanism of action of the hypnotic zol. in vivo. Br.J.Pharmacol. 131 1251 PMID: 11090095

Depoortere et al (1986) Zolpidem, a novel nonbenzodiazepine hypnotic. 1. Neuropharmacological and behavioural effects. J.Pharmacol.Exp.Ther. 237 649 PMID: 2871178

Perrault et al (1992) Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zol. J.Pharmacol.Exp.Ther. 263 298 PMID: 1403792

Soderhielm et al (2018) Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors. Biochem.Pharmacol. 158 339 PMID: 30121248


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Keywords: Zolpidem, Zolpidem supplier, Benzodiazepine, agonists, GABAA, Receptors, 0655, Tocris Bioscience

7 Citations for Zolpidem

Citations are publications that use Tocris products. Selected citations for Zolpidem include:

Seifi et al (2014) Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. Br J Cancer 34 10361 PMID: 25080596

Bowser et al (2002) Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy. Proc Natl Acad Sci U S A 99 15170 PMID: 12415111

Letra-Vilela et al (2016) Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin Molecular and Cellular Endocrinology 434 238 PMID: 27402603

Lazarus and Huang (2011) Distinct maturation profiles of perisomatic and dendritic targeting GABAergic interneurons in the mouse primary visual cortex during the critical period of ocular dominance plasticity. J Neurophysiol 106 775 PMID: 21613595

Kotak et al (2008) Hearing loss prevents the maturation of GABAergic transmission in the auditory cortex. J Neurosci 18 2098 PMID: 18222937

Wulff et al (2007) From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors. Nat Neurosci 10 923 PMID: 17572671

Geracitano et al (2012) Functional expression of the GABA(A) receptor α2 and α3 subunits at synapses between intercalated medial paracapsular neurons of mouse amygdala. Front Neural Circuits 6 32 PMID: 22666188


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