Benzodiazepine agonist with high selectivity for α1-subunit-containing GABAA receptors (BZ/ω1 site) and very high intrinsic activity. Ki values are 20, 400 and ≥ 5000 nM for α1-, α2-/α3-, and α5-containing GABAA receptors respectively. Hypnotic that does not induce physical dependence.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 307.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.25 mL||16.27 mL||32.53 mL|
|5 mM||0.65 mL||3.25 mL||6.51 mL|
|10 mM||0.33 mL||1.63 mL||3.25 mL|
|50 mM||0.07 mL||0.33 mL||0.65 mL|
References are publications that support the products' biological activity.
Arbilla et al (1986) High affinity [3H]zolpidem binding in the rat brain: an imidazopyridine with agonist properties at central benzodiazepine receptors. Eur.J.Pharmacol. 130 257 PMID: 2878820
Crestani et al (2000) Mechanism of action of the hypnotic zolpidem in vivo. Br.J.Pharmacol. 131 1251 PMID: 11090095
Depoortere et al (1986) Zolpidem, a novel nonbenzodiazepine hypnotic. 1. Neuropharmacological and behavioural effects. J.Pharmacol.Exp.Ther. 237 649 PMID: 2871178
Perrault et al (1992) Lack of tolerance and physical dependence upon repeated treatment with the novel hypnotic zolpidem. J.Pharmacol.Exp.Ther. 263 298 PMID: 1403792
If you know of a relevant reference for Zolpidem, please let us know.
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Keywords: Zolpidem, supplier, Benzodiazepine, agonists, GABAA, Receptors, GABAA, Receptors, GABAA, Receptors, Tocris Bioscience
5 Citations for Zolpidem
Citations are publications that use Tocris products. Selected citations for Zolpidem include:
Seifi et al (2014) Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. Br J Cancer 34 10361 PMID: 25080596
Letra-Vilela et al (2016) Distinct roles of N-acetyl and 5-methoxy groups in the antiproliferative and neuroprotective effects of melatonin Molecular and Cellular Endocrinology 434 238 PMID: 27402603
Lazarus and Huang (2011) Distinct maturation profiles of perisomatic and dendritic targeting GABAergic interneurons in the mouse primary visual cortex during the critical period of ocular dominance plasticity. J Neurophysiol 106 775 PMID: 21613595
Kotak et al (2008) Hearing loss prevents the maturation of GABAergic transmission in the auditory cortex. J Neurosci 18 2098 PMID: 18222937
Bowser et al (2002) Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy. Proc Natl Acad Sci U S A 99 15170 PMID: 12415111
Do you know of a great paper that uses Zolpidem from Tocris? If so please let us know.
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