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Biological Activity for ZM 336372
ZM 336372 is a potent, selective inhibitor of c-Raf in vitro (IC50 = 70 nM for inhibition of human c-Raf). Shows 10-fold selectivity over B-Raf. Also inhibits SAPK2/p38 (IC50 = 2 μM). Selective over 17 other protein kinases including PKA, PKC, p42 MAPK, CDK1 and SAPK1/JNK (up to 50 μM).
Sold with the permission of AstraZeneca Ltd
Compound Libraries for ZM 336372
Technical Data for ZM 336372
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ZM 336372
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for ZM 336372
The following data is based on the product molecular weight 389.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.57 mL||12.84 mL||25.68 mL|
|5 mM||0.51 mL||2.57 mL||5.14 mL|
|10 mM||0.26 mL||1.28 mL||2.57 mL|
|50 mM||0.05 mL||0.26 mL||0.51 mL|
References for ZM 336372
References are publications that support the biological activity of the product.
Hall-Jackson et al (1999) Paradoxical activation of Raf by a novel Raf inhibitor. Chem.Biol. 6 559 PMID: 10421767
Wartenberg et al (2001) Down-regulation of intrinsic p-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species. J.Biol.Chem. 276 17420 PMID: 11279018
If you know of a relevant reference for ZM 336372, please let us know.
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Keywords: ZM 336372, ZM 336372 supplier, Potent, selective, c-Raf, inhibitors, inhibits, Kinases, ZM336372, AstraZeneca, Raf, Kinase, 1321, Tocris Bioscience
4 Citations for ZM 336372
Citations are publications that use Tocris products. Selected citations for ZM 336372 include:
Deming et al (2010) ZM336372 induces apoptosis associated with phosphorylation of GSK-3β in pancreatic adenocarcinoma cell lines. J Neurosci 161 28 PMID: 20031160
Alao et al (2006) Role of glycogen synthase kinase 3 β (GSK3β) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells. J Surg Res 5 40 PMID: 17018141
Stockand (2003) Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1/2 signaling. Am J Physiol Heart Circ Physiol 284 H176 PMID: 12388314
Lourenco et al (2015) Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol 194 3463 PMID: 25712213
Do you know of a great paper that uses ZM 336372 from Tocris? Please let us know.
Reviews for ZM 336372
Average Rating: 5 (Based on 1 Review.)
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All MAPK inhibitors (ZM336372: c-RAF inhibitor; UO126: MEK1/MEK2 inhibitor, SB203580: p38 inhibitor) were used at 10 μM
We ordered this product, combining with another inhibitor, to confirm the migration.To confirm that tested product induces migration, we also screen all MAPK inhibitors and MIF receptor antagonists
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.