ZK 93423 hydrochloride

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Cat.No. 1994 - ZK 93423 hydrochloride | C23H22N2O4.HCl | CAS No. 1216574-52-5
Description: Potent benzodiazepine agonist
Chemical Name: 4-(Methoxymethyl)-6-(phenylmethoxy)-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester hydrochloride
Purity: ≥98% (HPLC)
Literature (7)

Biological Activity

Potent benzodiazepine receptor agonist (IC50 = 1 nM). Non-selective between α1-, α2-, α3- and α5-subunit containing GABAA receptors (Ki values are 4.1, 4.2, 6 and 4.5 nM for inhibition of [3H]Ro15-1788 binding to human recombinant α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2 receptors respectively). Anxiolytic following systemic administration in vivo.

Technical Data

M. Wt 426.9
Formula C23H22N2O4.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1216574-52-5
PubChem ID 56972166
Smiles Cl.CCOC(=O)C1=C(COC)C2=C(NC3=C2C=C(OCC2=CC=CC=C2)C=C3)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 11.71 30
ethanol 1.95 5

Preparing Stock Solutions

The following data is based on the product molecular weight 426.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.3 mM 7.81 mL 39.04 mL 78.08 mL
1.5 mM 1.56 mL 7.81 mL 15.62 mL
3 mM 0.78 mL 3.9 mL 7.81 mL
15 mM 0.16 mL 0.78 mL 1.56 mL

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References are publications that support the biological activity of the product.

Stephens et al (1984) Discriminative stimulus properties of β-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors. Psychopharmacology 83 233 PMID: 6089245

File and Baldwin (1987) Effects of β-carbolines in animal models of anxiety. Brain Res.Bull. 19 293 PMID: 3315125

Cox et al (1998) Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (ZK 934 J.Med.Chem. 41 2537 PMID: 9651158

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