ZK 93423 hydrochloride

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Cat.No. 1994 - ZK 93423 hydrochloride | C23H22N2O4.HCl | CAS No. 1216574-52-5
Description: Potent benzodiazepine agonist
Chemical Name: 4-(Methoxymethyl)-6-(phenylmethoxy)-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent benzodiazepine receptor agonist (IC50 = 1 nM). Non-selective between α1-, α2-, α3- and α5-subunit containing GABAA receptors (Ki values are 4.1, 4.2, 6 and 4.5 nM for inhibition of [3H]Ro15-1788 binding to human recombinant α1β3γ2, α2β3γ2, α3β3γ2 and α5β3γ2 receptors respectively). Anxiolytic following systemic administration in vivo.

Compound Libraries

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Technical Data

M. Wt 426.9
Formula C23H22N2O4.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1216574-52-5
PubChem ID 56972166
InChI Key KHMDBPAODAAMBQ-UHFFFAOYSA-N
Smiles Cl.CCOC(=O)C1=C(COC)C2=C(NC3=C2C=C(OCC2=CC=CC=C2)C=C3)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.71 30
ethanol 1.95 5

Preparing Stock Solutions

The following data is based on the product molecular weight 426.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.3 mM 7.81 mL 39.04 mL 78.08 mL
1.5 mM 1.56 mL 7.81 mL 15.62 mL
3 mM 0.78 mL 3.9 mL 7.81 mL
15 mM 0.16 mL 0.78 mL 1.56 mL

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References

References are publications that support the biological activity of the product.

Stephens et al (1984) Discriminative stimulus properties of β-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors. Psychopharmacology 83 233 PMID: 6089245

File and Baldwin (1987) Effects of β-carbolines in animal models of anxiety. Brain Res.Bull. 19 293 PMID: 3315125

Cox et al (1998) Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (ZK 934 J.Med.Chem. 41 2537 PMID: 9651158


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Citations for ZK 93423 hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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