Zinc protoporphyrin IX

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Cat.No. 0746 - Zinc protoporphyrin IX | C34H32N4O4Zn | CAS No. 15442-64-5
Description: Heme oxygenase and guanylyl cyclase inhibitor
Chemical Name: 7,12-Diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropionic acid, zinc complex

Biological Activity

Inhibitor of heme oxygenase, which generates the putative neurotransmitter CO.

Technical Data

M. Wt 626.03
Formula C34H32N4O4Zn
Storage Store at RT
CAS Number 15442-64-5
PubChem ID 455799
Smiles C=CC1=C(/C=C3\N=C(/C=C(N5[Zn]6)/C(C)=C(CCC(O)=O)/C5=C4)C(C=C)=C3C)N6C(/C=C2/C(C)=C(CCC(O)=O)C/4=N2)=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 31.3 50

Preparing Stock Solutions

The following data is based on the product molecular weight 626.03. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.6 mL 7.99 mL 15.97 mL
5 mM 0.32 mL 1.6 mL 3.19 mL
10 mM 0.16 mL 0.8 mL 1.6 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet


References are publications that support the products' biological activity.

Brune and Ullrich (1987) Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase. Mol.Pharmacol. 32 497 PMID: 2890093

Grundemar and Ny (1997) Pitfalls using metalloporphyrins in carbon monoxide research. TiPS 18 193 PMID: 9226997

Luo and Vincen (1994) Metalloporphyrins inhibit nitric oxide-dependent cGMP formation in vivo. Eur.J.Pharmacol. 267 263 PMID: 7522180

Verma et al (1993) Carbon monoxide a putative neural messenger. Science 259 381 PMID: 7678352

If you know of a relevant reference for Zinc protoporphyrin IX, please let us know.

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