Tin protoporphyrin IX dichloride

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Cat.No. 0747 - Tin protoporphyrin IX dichloride | C34H32Cl2N4O4Sn | CAS No. 14325-05-4
Description: Heme oxygenase inhibitor
Citations (2)

Biological Activity

A potent inhibitor of heme oxygenase. Prevents hyperbilirubinemia in neonates.

Technical Data

M. Wt 750.25
Formula C34H32Cl2N4O4Sn
Storage Store at RT
CAS Number 14325-05-4
PubChem ID 3000478
Smiles C=CC1=C(/C=C3\N=C(/C=C(N5[Sn](Cl)6Cl)/C(C)=C(CCC(O)=O)/C5=C4)C(C=C)=C3C)N6C(/C=C2/C(C)=C(CCC(O)=O)C/4=N2)=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
1eq. NaOH 18.76 25
DMSO 3.75 5

Preparing Stock Solutions

The following data is based on the product molecular weight 750.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.33 mL 6.66 mL 13.33 mL
5 mM 0.27 mL 1.33 mL 2.67 mL
10 mM 0.13 mL 0.67 mL 1.33 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Drummond and Kappas (1981) Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of haem oxidation. Proc.Natl.Acad.Sci.U.S.A. 78 6466 PMID: 6947237

Grundemar and Ny (1997) Pitfalls using metalloporphyrins in carbon monoxide research. TiPS 18 193 PMID: 9226997

If you know of a relevant reference for Tin protoporphyrin IX dichloride, please let us know.

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2 Citations for Tin protoporphyrin IX dichloride

Citations are publications that use Tocris products. Selected citations for Tin protoporphyrin IX dichloride include:

Guimarães et al (2012) Mitochondrial uncouplers inhibit hepatic stellate cell activation. BMC Gastroenterol 12 68 PMID: 22686625

Ye et al (2013) Astaxanthin protects against MPP(+)-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis. BMC Neurosci 13 156 PMID: 23272707

Do you know of a great paper that uses Tin protoporphyrin IX dichloride from Tocris? If so please let us know.

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