Tin protoporphyrin IX dichloride

Pricing Availability Delivery Time Qty
Cat.No. 0747 - Tin protoporphyrin IX dichloride | C34H32Cl2N4O4Sn | CAS No. 14325-05-4
Description: Heme oxygenase inhibitor
Datasheet
Citations (2)
Literature

Biological Activity

A potent inhibitor of heme oxygenase. Prevents hyperbilirubinemia in neonates.

Technical Data

M. Wt 750.25
Formula C34H32Cl2N4O4Sn
Storage Store at RT
CAS Number 14325-05-4
PubChem ID 3000478
InChI Key ZUQBMBXSEXXKTO-UHFFFAOYSA-L
Smiles C=CC1=C(/C=C3\N=C(/C=C(N5[Sn](Cl)6Cl)/C(C)=C(CCC(O)=O)/C5=C4)C(C=C)=C3C)N6C(/C=C2/C(C)=C(CCC(O)=O)C/4=N2)=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 18.76 25
DMSO 3.75 5

Preparing Stock Solutions

The following data is based on the product molecular weight 750.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.33 mL 6.66 mL 13.33 mL
5 mM 0.27 mL 1.33 mL 2.67 mL
10 mM 0.13 mL 0.67 mL 1.33 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Drummond and Kappas (1981) Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of haem oxidation. Proc.Natl.Acad.Sci.U.S.A. 78 6466 PMID: 6947237

Grundemar and Ny (1997) Pitfalls using metalloporphyrins in carbon monoxide research. TiPS 18 193 PMID: 9226997


If you know of a relevant reference for Tin protoporphyrin IX dichloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Heme Oxygenase Inhibitors

Keywords: Tin protoporphyrin IX dichloride, supplier, Heme, haem, oxygenase, inhibitors, inhibits, Oxygenases, Oxidases, Tin, protoporphyrinIX, dichloride, Heme, Oxygenase, Tocris Bioscience

2 Citations for Tin protoporphyrin IX dichloride

Citations are publications that use Tocris products. Selected citations for Tin protoporphyrin IX dichloride include:

Ye et al (2013) Astaxanthin protects against MPP(+)-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis. BMC Neurosci 13 156 PMID: 23272707

GuimarĂ£es et al (2012) Mitochondrial uncouplers inhibit hepatic stellate cell activation. BMC Gastroenterol 12 68 PMID: 22686625


Do you know of a great paper that uses Tin protoporphyrin IX dichloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Tin protoporphyrin IX dichloride

Protocols

TODO: Add Protocols